https://www.jrnls.org/ijper New articles published in Indian Journal of Pharmaceutical Education and Research. en Tue, 08 Sep 2026 00:00:00 GMT https://www.jrnls.org/ijper/60/4s/1364 https://www.jrnls.org/ijper/60/4s/1364 Tue, 08 Sep 2026 00:00:00 GMT Deepak Thakre, Priyanka Singanwad, Milind Umekar, Amol Tatode, Nishant Awandekar, Mohammad Qutub, Ujban Mohammad Hussain Indian Journal of Pharmaceutical Education and Research Resistance is one of the major problems in chemotherapy during Breast Cancer (BC) treatment. Earlier treatments, such as radiation, surgery, and chemotherapy including taxane-based therapies like paclitaxel and docetaxel, play a crucial role in managing BC, particularly in aggressive subtypes like Human Epidermal Growth Factor Receptor-2 (HER-2) positive and Triple-Negative Breast Cancer (TNBC). Taxanes disrupt cell division by stabilizing microtubules, inducing apoptosis in rapidly dividing… https://www.jrnls.org/ijper/60/4s/1374 https://www.jrnls.org/ijper/60/4s/1374 Tue, 08 Sep 2026 00:00:00 GMT Rashed M Almuqbil, Bandar Aldhubiab, Mueen Ahmed K. K, Chaman Sab M Indian Journal of Pharmaceutical Education and Research Background: Interest in natural products-polyphenols, flavonoids, terpenoids, and related phytochemicals-as candidate senotherapeutic and geroprotective agents has expanded rapidly over the past decade, yet the literature spans pharmacology, cosmetic science, food chemistry, and model-organism biology in ways that are difficult to map through narrative review alone. This study provides a scientometric analysis of the global research landscape connecting natural products to cellular senescence… https://www.jrnls.org/ijper/60/4s/1383 https://www.jrnls.org/ijper/60/4s/1383 Tue, 08 Sep 2026 00:00:00 GMT Km. Anjali, Arun Kumar Mishra Indian Journal of Pharmaceutical Education and Research Pyrrolidine is a saturated five-membered nitrogen-containing heterocycle widely recognized as a privileged scaffold in medicinal chemistry. Its conformational flexibility, strong basicity, and hydrogen-bonding capability contribute to its broad pharmacological relevance. Pyrrolidine derivatives exhibit diverse biological activities, including antimicrobial, anticancer, antiviral, anti-inflammatory, neuropharmacological, and antidiabetic effects. Several clinically approved drugs such as… https://www.jrnls.org/ijper/60/4s/1405 https://www.jrnls.org/ijper/60/4s/1405 Tue, 08 Sep 2026 00:00:00 GMT Manisha Dnyanoba Chate, Swaroop Rameshwarji Lahoti Indian Journal of Pharmaceutical Education and Research Introduction: Ivacaftor a drug falling under BCS class II due to its low solubility, with a bioavailability of around 20%. In this study, the novel liquisolid technique is used to enhance the dissolution and ultimately improve the solubility. Objectives: The primary objective was to increase the efficiency of the drug, particularly in lower doses. Materials and Methods: The formulation containing 25 mg liquisolid ivacaftor tablet was prepared through a multi-step process. Initially, assessed… https://www.jrnls.org/ijper/60/4s/1416 https://www.jrnls.org/ijper/60/4s/1416 Tue, 08 Sep 2026 00:00:00 GMT Vidhan Chand Bala, Mukesh Kumar Singh, Amit Kumar, Arvind Kumar Patel, Sunil Kumar Tiwari, Asheesh Kumar Gupta, Sushil Kumar Indian Journal of Pharmaceutical Education and Research Objectives: This study aimed to develop polymer-conjugated Fast Dissolving Tablets (FDTs) of ambroxol hydrochloride using direct compression with Amberlite IPR64 and Sodium Starch Glycolate (SSG) to achieve effective taste masking and enhance palatability and patient compliance. Materials and Methods: A 3² factorial design was employed to optimize formulation variables, producing nine formulation batches (F1-F9). Both Amberlite IRP64 (X1-20- 80 mg) and SSG (X2-10-30 mg) levels are independent… https://www.jrnls.org/ijper/60/4s/1430 https://www.jrnls.org/ijper/60/4s/1430 Tue, 08 Sep 2026 00:00:00 GMT Anurag Rajendra Panade, Sandip Akaram Bandgar, Riya Raghunath Patil, Indrayani Sandip Bandgar Indian Journal of Pharmaceutical Education and Research Introduction: This research focuses on formulating a thermoresponsive in situ gel containing Carvedilol for ocular delivery, employing a Quality by Design (QbD) strategy to improve therapeutic effectiveness in glaucoma management. Carvedilol, known for its β- and α1-blocking effects along with antioxidant activity, holds potential in reducing Intraocular Pressure (IOP) and protecting retinal cells. However, its therapeutic performance is hindered by poor retention and low bioavailability when… https://www.jrnls.org/ijper/60/4s/1445 https://www.jrnls.org/ijper/60/4s/1445 Tue, 08 Sep 2026 00:00:00 GMT Jitendra Singh, Prateek Sahu, Sharad Prakash Pandey, Rajesh Kumar Maheshwari Indian Journal of Pharmaceutical Education and Research Aim: The objective of this research was to investigate the mixed solvency concept as a means to enhance the solubility of Piroxicam and to develop an optimized microemulsion-based gel formulation suitable for topical application. Materials and Methods: Piroxicam-loaded microemulsion gel was prepared by using a combination of a pseudo-ternary phase diagram and a D-Optimal mixture design approach. This involved conducting 15 trial runs with three key variables: the percentage of oil blend, water… https://www.jrnls.org/ijper/60/4s/1461 https://www.jrnls.org/ijper/60/4s/1461 Tue, 08 Sep 2026 00:00:00 GMT Zainab Eassa Jassim, Nawal Ayash Rajab, Hamid Akbari Javar Indian Journal of Pharmaceutical Education and Research Objectives: An effort has been utilized to incorporate ASPM into polymeric micelles using single and mixed copolymers. Materials and Methods: A thin-film hydration approach was used to create the ASPM polymeric micelles, which comprised TPGS, Solutol®HS-15, and Pluronics. Micelles characterization was performed by particle size distribution, zeta potential, while Encapsulation Efficiency (EE%), Drug Loading (DL%) content and in vitro drug release were determined also by HPLC analysis. Results:… https://www.jrnls.org/ijper/60/4s/1474 https://www.jrnls.org/ijper/60/4s/1474 Tue, 08 Sep 2026 00:00:00 GMT Deepak Sharma, Dipanjan Koley, Khushbu Mehlawat, Kavita Attri, Vijay Bhalla, Manvi Singh Indian Journal of Pharmaceutical Education and Research Background: The Indian cosmetic industry is experiencing rapid growth, valued at USD 8.1 billion in 2023 and projected to reach USD 18.4 billion by 2032. Among cosmetic products, lipsticks are widely used and frequently applied, raising concerns regarding cumulative exposure to potentially harmful substances such as toxic heavy metals. Previous studies have reported contamination of cosmetics with elements like lead, cadmium, chromium, and arsenic, emphasizing the need for strict quality… https://www.jrnls.org/ijper/60/4s/1486 https://www.jrnls.org/ijper/60/4s/1486 Tue, 08 Sep 2026 00:00:00 GMT Anilkumar Shinde, Nikita Gurav, Harinath More Indian Journal of Pharmaceutical Education and Research Background: Palbociclib (PCB), a selective cyclin-dependent kinase 4/6 prescribe for hormone receptor-positive breast cancer, has low oral bioavailability and dose-limiting systemic toxicity. Objectives: In order to achieve prolonged drug administration and improved transdermal penetration, the current work sought to create and optimize a transdermal patch containing PCB based on Nanostructured Lipid Carriers (NLCs). Materials and Methods: After being adsorbed onto Neusilin® US2, PCB-NLCs were… https://www.jrnls.org/ijper/60/4s/1498 https://www.jrnls.org/ijper/60/4s/1498 Tue, 08 Sep 2026 00:00:00 GMT Abdullah M. Alotaibi, Anroop B. Nair, Hiral Shah, Bandar Aldhubiab, Shery Jacob, Rashed M. Almuqbil, Ahmed S. Alnaim, Jigar N. Shah Indian Journal of Pharmaceutical Education and Research Background: Chronic wounds remain a major clinical challenge due to impaired angiogenesis, persistent inflammation, and oxidative stress, necessitating advanced therapeutic strategies. The purpose of this research was to design, develop and evaluate deferoxamine loaded nanoemulgel for enhanced topical delivery and wound healing. Materials and Methods: Deferoxamine loaded nanoemulsions were formulated by aqueous titration method using oleic acid, Tween 80, and propylene glycol as oil,… https://www.jrnls.org/ijper/60/4s/1514 https://www.jrnls.org/ijper/60/4s/1514 Tue, 08 Sep 2026 00:00:00 GMT Lamia Yasmin, Soumen Dhara, Surajit Ghosh, Satyaki Pachal, Sumit Jana, Dibya Das, Rania Indu, Moumita Ray Indian Journal of Pharmaceutical Education and Research Background: Myocardial Infarction (MI), driven by oxidative stress-induced cardiomyocyte injury, is the most predisposing disease, causing prevalent mortality globally, among the various cardiovascular diseases. Present study evaluated the cardioprotective potential of the methanolic extract of Mikania micrantha leaves (MME) in experimental animal model. Materials and Methods: The extract was evaluated for its phytochemical analysis, antioxidant and anti-inflammatory activities.… https://www.jrnls.org/ijper/60/4s/1523 https://www.jrnls.org/ijper/60/4s/1523 Tue, 08 Sep 2026 00:00:00 GMT Bhasha Shanmugam, Kondeti Ramudu Shanmugam, Meesala Gurusekhar, Ramavath Kambli Naik, Dronadula Veena Madhuri, Sahukari Ravi Indian Journal of Pharmaceutical Education and Research Background: Phyllanthus niruri (PN), known as Bhumyamalaki and it has been used in Ayurveda to treat liver, kidney and spleen related disorders. But till date no study was carried on the antihepatitis activity of phenolic fraction of PN. The objective of the current study was to investigate the antihepatitic, antioxidant and hepatoprotective effect of phenolic fraction of Phyllanthus niruri against hepatitis in rats. Materials and Methods: Wistar strain albino rats were divided in to 5 groups… https://www.jrnls.org/ijper/60/4s/1532 https://www.jrnls.org/ijper/60/4s/1532 Tue, 08 Sep 2026 00:00:00 GMT Armugam Jayasankar, Hanumanthu Rama Subba Reddy, Marapa Reddy Sowghandika, Amgoth Govardhan Naik, Narasaiah Shivakoti, Paluru Subramanyam, Kanala Somasekhar Reddy, Devarapalle Veera Nagendra Kumar, Vempapti Uday Kiran Indian Journal of Pharmaceutical Education and Research Aim: Curcumin, the primary bioactive agent in Curcuma longa (turmeric), is celebrated in Ayurveda for its anti-inflammatory, antioxidant, and wound-healing effects. Its clinical application is limited by poor bioavailability, despite its traditional use in treating respiratory, liver, and skin disorders. Curcumin nanoparticles produced through green synthesis improve solubility, stability, and targeted delivery, demonstrating significant promise for the treatment of breast and colon cancer.… https://www.jrnls.org/ijper/60/4s/1544 https://www.jrnls.org/ijper/60/4s/1544 Tue, 08 Sep 2026 00:00:00 GMT Richa Yadav, Jaya Parkash Yadav Indian Journal of Pharmaceutical Education and Research Aim: Polycystic ovary syndrome is a prevalent endocrine disorder that arises from hormonal imbalance, typically presenting with excessive androgen production, disrupted ovulatory cycles, and various metabolic abnormalities. Current pharmacological options often cause side effects and show inconsistent efficacy, highlighting the need for safer alternatives. The present study aimed to investigate the phytoconstituents of Diplocyclos palmatus (L.) C. Jeffrey methanolic seed extract and evaluate… https://www.jrnls.org/ijper/60/4s/1553 https://www.jrnls.org/ijper/60/4s/1553 Tue, 08 Sep 2026 00:00:00 GMT Jawaher Amer Alsaiari, Abdulraheem A. Almalki, Jawaher Ayidh Alosaimi, Raja Mohammed Al-Qurashi, Bedour Abdullah Al-Qurashi, Fatima Anwar Dhafer, Ahad Amer Alsaiari Indian Journal of Pharmaceutical Education and Research Background: Globally, Breast Cancer (BC) ranks as the second most common cause of cancer-related death for women. The high mortality and recurrence rates contribute substantially to its fatality. Objectives: This research focused to investigate the anti-cancer potential of Cucurbitacin-B (Cu-B) against the human breast cancer cell line MCF-7, focusing on the Fas/ FasL-mediated death receptor signalling pathway. Materials and Methods: The anti-proliferative effect of Cu-B was assessed using the… https://www.jrnls.org/ijper/60/4s/1563 https://www.jrnls.org/ijper/60/4s/1563 Tue, 08 Sep 2026 00:00:00 GMT Nael Abutaha, Fahd Abdo Al-Mekhlafi, Mohammed A. Wadaan Indian Journal of Pharmaceutical Education and Research Background: Juglans regia leaves contain bioactive compounds with potential anticancer effects. This study evaluated their cytotoxic activity and interactions with cancer-related targets. Materials and Methods: Leaves of J. regia were subjected to Soxhlet and ultrasonic extraction using different solvents. Extract yields were calculated, and antioxidant activity was assessed using the DPPH• assay. Cytotoxicity was evaluated against MCF-7, HepG2, and Huvec cell lines. Apoptotic changes were… https://www.jrnls.org/ijper/60/4s/1573 https://www.jrnls.org/ijper/60/4s/1573 Tue, 08 Sep 2026 00:00:00 GMT Sanjita Das, Shruti Dhasmana, Gyas Khan Indian Journal of Pharmaceutical Education and Research Objectives: This study is targeted at investigating the nanogel formulation of a protein from the milk of goat; CSN1S2 for anxiolytic activity in mice. Materials and Methods: After isolating CSNIS2, its nanogel was formulated by emulsification diffusion method. The nanogels' physical appearance, particle size, viscosity, spreadability, Zeta potential, particle size, Zeta potential, and in vitro diffusion profile were observed. Fourier transform infrared diffraction was used to characterize the… https://www.jrnls.org/ijper/60/4s/1580 https://www.jrnls.org/ijper/60/4s/1580 Tue, 08 Sep 2026 00:00:00 GMT Mohammad Zubair Alam, Hala Abubaker Bagabir, Mohammad Alameen Faisal Zaher, Thamer Mohammed Ahmed Alqurashi, Badrah Saeed Alghamdi, Mohsin Kazi, Athanasios Alexiou, Ghulam Md Ashraf Indian Journal of Pharmaceutical Education and Research Background: Neuroinflammation plays a critical role in the progression of neurodegenerative diseases such as multiple sclerosis, Alzheimer's, and Parkinson's disease. The Cuprizone (CPZ)- induced model is widely used to study neuroinflammatory mechanisms, as it selectively targets oligodendrocytes, causing demyelination and oxidative stress. Objectives: This study investigates the neuroprotective effects of curcumin nanoformulations prepared in Zanthoxylum rhetsa seed oil against CPZ-induced… https://www.jrnls.org/ijper/60/4s/1594 https://www.jrnls.org/ijper/60/4s/1594 Tue, 08 Sep 2026 00:00:00 GMT Navaneethakrishnan Subramanian, Vijayaraj Surendran, Rajkumar Selvam, Murugesan Vanangamudi, Thiruveni Azhagarsamy, Raghavendra Kumar Gunda Indian Journal of Pharmaceutical Education and Research Background: Bone cancer, particularly osteosarcoma, is an aggressive malignancy with poor prognosis, often resistant to conventional chemotherapy. Protocatechuic Acid (PCA), a plant-derived polyphenol, holds anticancer potential but suffers from poor bioavailability. Materials and Methods: This study investigated the cytotoxic and apoptotic effects of PCA Nanosuspensions (PCA-NS) on MG-63 human osteosarcoma cells and evaluated its molecular interactions via docking with two target proteins,… https://www.jrnls.org/ijper/60/4s/1604 https://www.jrnls.org/ijper/60/4s/1604 Tue, 08 Sep 2026 00:00:00 GMT Urvashi Zamindar, Rajesh Khathuriya Indian Journal of Pharmaceutical Education and Research The study titled “GI50 inhibition study using Sulforhodamine B (SRB) assay method on breast cancer cell line (MCF-7) using ethanolic extracts of leaves of Chromolaena odorata and Capparis moonii” investigates the anticancer potential of leaf extracts. Objectives: The research focuses on assessing the effects of ethanolic extracts of leaves of both plants and their combination using the Sulforhodamine B assay. Materials and Methods: These extracts of selected plants' leaves were prepared by… https://www.jrnls.org/ijper/60/4s/1610 https://www.jrnls.org/ijper/60/4s/1610 Tue, 08 Sep 2026 00:00:00 GMT Veerappan Rajkumar, Balsubramanian Sivakumar, Savari Prabhu Indian Journal of Pharmaceutical Education and Research Aim/Background: In order to capture significant structural features of chemical compounds, this study presents three new topological indices: the Fragment-Weighted Connectivity Index (FWCI), the Distance-Weighted Subgraph Index (DWSI), and the Symmetry-Based Informational Index (SBI). In order to provide improved molecular descriptors for Quantitative Structure-Property Relationship (QSPR) modelling, these indices seek to represent molecular symmetry, spatial arrangement, and functional group… https://www.jrnls.org/ijper/60/4s/1630 https://www.jrnls.org/ijper/60/4s/1630 Tue, 08 Sep 2026 00:00:00 GMT Shital Prashant Dehankar, Ratnadip Rajabhau Joshi Indian Journal of Pharmaceutical Education and Research Background: The Hydrodynamic Cavitation (HC) is a promising, energy-saving method to remove micropollutants such as metformin in water. There are however difficulty in optimisation of the performance of HC reactor as the cavitation behaviour is geometry dependant and the operating parameters interact in complex and non-linear ways. Nevertheless, there is still a challenge in optimising reactor performance among various device geometries (Venturi and orifice) because there are intricate… https://www.jrnls.org/ijper/60/4s/1641 https://www.jrnls.org/ijper/60/4s/1641 Tue, 08 Sep 2026 00:00:00 GMT Khloud H Alsaadi Indian Journal of Pharmaceutical Education and Research Background: Pseudomonas aeruginosa is a clinically significant opportunistic bacterium that exhibits intrinsic antimicrobial resistance, biofilm formation, and quorum-sensing-regulated virulence. Nowadays, plant-derived compounds are gaining attention as alternative agents for targeting bacterial virulence pathways. Objectives: This study aimed to determine the efficacy of Ferulic Acid (FA) against P. aeruginosa by antibacterial, anti-biofilm formation and anti-quorum sensing activity.… https://www.jrnls.org/ijper/60/4s/1650 https://www.jrnls.org/ijper/60/4s/1650 Tue, 08 Sep 2026 00:00:00 GMT Nagendra Prasad Krishnamurthy, Sanskruti Patil, Vinu Vijayakumar, Raghu Chandrashekar Hariharapura, Srikanth Nagaraja Jois Indian Journal of Pharmaceutical Education and Research Background: Parkinson’s Disease (PD) involves dopaminergic neurodegeneration associated with mitochondrial dysfunction, oxidative stress, and apoptosis. Objectives: To evaluate the effects of Pranic Healing (PH) colour exposures on dopamine-induced cytotoxicity, Mitochondrial Membrane Potential (MMP), apoptosis, and oxidative stress in SH-SY5Y neuroblastoma cells. Materials and Methods: SH-SY5Y cells were exposed to rotenone to induce neurotoxicity and treated with dopamine followed by… https://www.jrnls.org/ijper/60/4s/1657 https://www.jrnls.org/ijper/60/4s/1657 Tue, 08 Sep 2026 00:00:00 GMT Yahya Hasan Hobani Indian Journal of Pharmaceutical Education and Research Background: Conessine is a steroidal alkaloid with diverse pharmacological activities, but its anticancer potential against melanoma and the mode of action remain poorly understood. Objectives: The present study evaluated the anticancer activity of conessine against human melanoma SK-MEL-28 cells and investigated its involvement in mitochondrial-mediated apoptosis. Materials and Methods: The cytotoxic effect of conessine was assessed using the MTT assay. Mitochondrial superoxide generation,… https://www.jrnls.org/ijper/60/4s/1669 https://www.jrnls.org/ijper/60/4s/1669 Tue, 08 Sep 2026 00:00:00 GMT Akshay Kalgonda Patil, Abhishek Chandrashekhar Teli, Sachin Paragouda Gudasi, Adarsh Chidanand Umarani Indian Journal of Pharmaceutical Education and Research Background: Trigonelline is alkaloid known for its exceptional biological activities. The aim of the present work was to develop and validate Quality by Design based RP-HPLC method for estimation of trigonelline. Materials and Methods: The optimization process involves the design of experiments, utilizing response surface plots, contour plots, and overlay plots. The effective implementation of this method leads to a reduced retention time of 3 min, utilizing a reversed-phase C-18 column (5 mm,… https://www.jrnls.org/ijper/60/4s/1679 https://www.jrnls.org/ijper/60/4s/1679 Tue, 08 Sep 2026 00:00:00 GMT Srishti Morris, Ashutosh Badola, Bhawana Kapoor, Nidhi Gairola Indian Journal of Pharmaceutical Education and Research Background: The purpose of this study was to formulate and evaluate Mouth-Dissolving Films (MDF) of Sumatriptan Succinate with super disintegrating agent Polacrilin Potassium, aimed at providing a fast and efficient delivery system for migraine relief. The patient can consume the formulation without water because the films are made to dissolve in few seconds when they come into touch with a wet surface, such the tongue. It results in increased patient compliance. Objectives: The present study… https://www.jrnls.org/ijper/60/4s/1688 https://www.jrnls.org/ijper/60/4s/1688 Tue, 08 Sep 2026 00:00:00 GMT Rajani Thoutreddy, Chakravarthi Guntupalli, Rajeshwari Pasupula, Anka Rao Areti, Pavani Sriram Indian Journal of Pharmaceutical Education and Research Background: Cubosomal gels have emerged as a favourable mode for delivery of drugs, contributing to release of drug in controlled mode with increased effectiveness. The study aimed to develop an optimized cubosomal gel formulation containing Lidocaine Hydrochloride for sustained pain relief, particularly in post-operative pains. Materials and Methods: Bottom-up method of approach was employed to prepare cubosomes utilizing Glyceryl Mono Oleate (GMO) and Poloxamer 407 (P-407). The formulations… https://www.jrnls.org/ijper/60/4s/1696 https://www.jrnls.org/ijper/60/4s/1696 Tue, 08 Sep 2026 00:00:00 GMT Lalitha Repudi, Baby Nalanda Revu, Buggana Siva Jyothi, Raghavarapu Prasanthi, Vasanth P M, Swetha Sri Remidicherla Indian Journal of Pharmaceutical Education and Research Background: Cinacalcet HCl is used to treat hyperthyroidism and hypercalcisim. QbD approach used to assess risk and develop cleaning method for Cinacalcet HCl. The Method Operable Design Region (MODR) was obtained by CCD concluded from surface and contour plot Analytical Target Profile defined with 15 variables verified for quality. Materials and Methods: The contour diagram displays the anticipated and optimized data, which includes the composition of the eluent phase consisting of potassium…