https://www.jrnls.org/ijpi New articles published in International Journal of Pharmaceutical Investigation. en Tue, 01 Dec 2026 00:00:00 GMT https://www.jrnls.org/ijpi/17/1/1 https://www.jrnls.org/ijpi/17/1/1 Tue, 01 Dec 2026 00:00:00 GMT Gogula Priya, Chinthaginjala Haranath, Donnepati Pradeep Sai, Konda Sai Megha, Sugur Samhitha, Vallapureddy Vasanthi, Kopparapu Maddi Venkata Ramu, Talapula Santhosh Kumar, Lingadahalli Bilwa Malini, Kotra Mounika International Journal of Pharmaceutical Investigation Cannabis sativa is the primary source of phytocannabinoids, which are meroterpenoids with a resorcinol core that are also present in other plant species such as Helichrysum and Echinacea. There are over more than 100 phytocannabinoids known to exist, delta-9-tetrahydrocannabinol (Δ-9THC), Cannabidiol (CBD) and Cannabigerol (CBG) are the most commonly used. Based on lead structures, these compounds are categorized into eleven major chemical classes. The effects of phytocannabinoids on… https://www.jrnls.org/ijpi/17/1/9 https://www.jrnls.org/ijpi/17/1/9 Tue, 01 Dec 2026 00:00:00 GMT Kaniga Pandi, Binoy Varghese Cheriyan, Kumaraguru, Bhavya Ekambaram, Arunpandiyan Jeyakumar, Inigo Pathuvairajan, Jai Anand Jagadeesan, Dinesh Kumar Eshwaravelu, Pradhosh Sakthivel, Rajeshkumar Thirupathi International Journal of Pharmaceutical Investigation Rabies remains a fatal zoonotic disease and a significant public health concern, particularly in underdeveloped countries. Although effective vaccines exist, early diagnosis and timely intervention are limited due to the lack of reliable, non-invasive diagnostic methods. Conventional techniques, such as direct fluorescent antibody testing of brain tissue and invasive sampling methods like cerebrospinal fluid analysis or skin biopsies, are often impractical in low-resource and field settings.… https://www.jrnls.org/ijpi/17/1/21 https://www.jrnls.org/ijpi/17/1/21 Tue, 01 Dec 2026 00:00:00 GMT Brahmaiah Bonthagarala, Sirisha Arige, Gadamsetti Naga Sai AnupamaSri, Mathi Queeny Hadassa, Chekuri Jahnavi, Choppala Jhaneesha, Kandukuri Sri Venkata Lakshmi, Kasilinka Kavya Sri, Rama Rao Vadapalli International Journal of Pharmaceutical Investigation Breast cancer remains a ubiquitous malignancy affecting women across the world, especially in aggressive subtypes like triple-negative breast cancer and HER2-positive tumors. Although conventional modalities like chemotherapy and targeted monoclonal antibodies have improved outcomes, challenges including drug resistance and systemic toxicity persist. Recent advancements in nanotechnology, particularly the development of silver nanoparticles, have promising effects in cancer therapy due to their… https://www.jrnls.org/ijpi/17/1/30 https://www.jrnls.org/ijpi/17/1/30 Mon, 01 Mar 2027 00:00:00 GMT Kaniga Pandi, Binoy Varghese Cheriyan, Sudharshini Srinivasan, Praveen Kumar Ramesh, Bhuvanesh Raj, Preethi Harikrishnan, Sharmila Sakthisivanandhan, Jubilee Ramsamy, Yokesh Shanmugam, Maha Swetha Kannuchamy, Arunpandiyan Jeyakumar, Inigo Pathuvairajan, Mathesvaran Thirunavukarasu International Journal of Pharmaceutical Investigation Bone remodeling is a tightly regulated physiological process governed by the coordinated activities of bone-forming osteoblasts and bone-resorbing osteoclasts. Emerging evidence highlights the immune system as a critical regulator of this process through complex cellular interactions and signaling networks, giving rise to the concept of osteoimmunology. Immune cells, including T cells, B cells, and macrophages, modulate bone homeostasis by secreting cytokines and engaging in direct cell-cell… https://www.jrnls.org/ijpi/17/1/51 https://www.jrnls.org/ijpi/17/1/51 Tue, 01 Dec 2026 00:00:00 GMT Madhavi Nimmathota, Billa Sravani, Medapatla Hari Priya, Uma Maheshwara Rao Vattikuti International Journal of Pharmaceutical Investigation Non-invasive nasal drug delivery systems have emerged as a promising route for drug administration. It facilitates rapid therapeutic effect, bypass first pass metabolism, increase patient compliance and provides nose-to-brain drug delivery. The nasal mucosa possesses high vascularization and large surface area enabling efficient uptake of both systemic and locally administered drugs. Nasal administration is especially beneficial in emergency situations such as migraines, seizures, and severe… https://www.jrnls.org/ijpi/17/1/63 https://www.jrnls.org/ijpi/17/1/63 Tue, 01 Dec 2026 00:00:00 GMT Chitrali Talele, Dipali Talele, Yogita Shinde, Archana Shaha, Niyati Shah, Chintan Aundhia International Journal of Pharmaceutical Investigation Mucosal drug delivery has emerged as a promising strategy for both local and systemic therapeutic administration due to its non-invasive nature and extensive absorptive surface area. However, the protective mucus barrier, composed of highly viscoelastic and adhesive mucin networks, significantly restricts the efficient transport of conventional nanocarriers. Traditional mucoadhesive systems, while improving retention, often suffer from limited diffusion and heterogeneous drug distribution… https://www.jrnls.org/ijpi/17/1/77 https://www.jrnls.org/ijpi/17/1/77 Tue, 01 Dec 2026 00:00:00 GMT Vandhana Vijayakumar, Thirumalaikumaran Rathinam, Subathra Sundar, Maheswari Murugan, Tarunika Balaji, Aswini Sreenivasan International Journal of Pharmaceutical Investigation Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine illnesses affecting women of reproductive age. It is distinguished by hyperandrogenism, ovulatory failure, and polycystic ovarian morphology. The syndrome is frequently linked to metabolic abnormalities such as insulin resistance, obesity, and an elevated risk of type 2 diabetes and cardiovascular disease. Conventional therapy treatments, such as pharmaceutical treatment and assisted reproductive technologies, are largely… https://www.jrnls.org/ijpi/17/1/86 https://www.jrnls.org/ijpi/17/1/86 Tue, 01 Dec 2026 00:00:00 GMT Kamalesh Dilip Mali, Sachin Yadav, Arya Nilesh Dubey, Gaurav Bharat Deore International Journal of Pharmaceutical Investigation Poor aqueous solubility remains a critical challenge in pharmaceutical development, leading to limited drug absorption, high variability in systemic exposure, and reduced therapeutic efficiency. Conventional approaches such as salt formation, amorphous systems, and lipid-based formulations often face limitations related to stability, scalability, and regulatory complexity. Drug nanocrystals have emerged as a clinically established strategy to address these challenges by enhancing dissolution… https://www.jrnls.org/ijpi/17/1/104 https://www.jrnls.org/ijpi/17/1/104 Tue, 01 Dec 2026 00:00:00 GMT Gorinkala Bhargavi Sudeeshna, M Mohan Varma, K.T. Sunil Kumar, Arumalla Sai Joshitha, Sujitha Pithani, Kesanapalli Uma Venkata Subba Prabha, Maitreya Paramkusam, Sudarshan Rao Nagineni International Journal of Pharmaceutical Investigation Personalized Medicine (PM) represents a paradigm shift from the traditional “one-size-fits-all” approach to personalized preventive, diagnostic, and treatment regimens tailored to individual genetic, biological, environmental, and lifestyle characteristics. Breakthroughs in genetics, pharmacogenomics, biomarker discovery, and targeted therapies have significantly improved disease prediction, treatment efficacy, and patient safety in cancer, infectious diseases, and chronic disorders. Focusing… https://www.jrnls.org/ijpi/17/1/115 https://www.jrnls.org/ijpi/17/1/115 Tue, 01 Dec 2026 00:00:00 GMT A Ashvil, Diya Kiran, Lenora Katherine Crasto, C G Deepak, Mariyammathul Afeeza, Bipin Shaji, Shivaprasad Sirimalla, Allen Pinto, Uday Venkat Mateti, Shrinivasa Undaru Bhat, Juno Jerold Joel International Journal of Pharmaceutical Investigation Although pharmacotherapy is a cornerstone in effectively managing mood fluctuations in bipolar disorder, adherence to prescribed medications often remains a challenge in the long run, to prevent recurrent episodes and hospitalizations. Nearly half of the patients are known to either discontinue the therapy or fail to follow the prescription schedule consistently. This challenge usually arises due to multifaceted factors including, complicated dosing schedules, poor insight of the disorder,… https://www.jrnls.org/ijpi/17/1/121 https://www.jrnls.org/ijpi/17/1/121 Tue, 01 Dec 2026 00:00:00 GMT Amit Anand, Aparna Inamdar, Bannimath Gurupadayya, Kushala Reddy, Mansi Sharma, Mohit Sharma, Arindam Kolay, Dipayan Rath, Romi Kumari Thakur, Himanshu Sharma International Journal of Pharmaceutical Investigation Skin cancer remains one of the most prevalent malignancies worldwide, and delayed diagnosis often leads to poor clinical outcomes. Recent advances in Artificial Intelligence (AI), particularly deep learning and computer vision, have revolutionized dermatological imaging analysis by enabling rapid and accurate detection of skin lesions. AI-assisted systems have emerged as valuable tools for improving diagnostic precision, prognostic evaluation, and accessibility to dermatological care. This… https://www.jrnls.org/ijpi/17/1/138 https://www.jrnls.org/ijpi/17/1/138 Mon, 01 Mar 2027 00:00:00 GMT NS Preetham, Sarath Mundra, M Shreeja, R Gagan, Gayathri Karnam, Akhilesh Dubey International Journal of Pharmaceutical Investigation Regulatory agencies have developed expedited drug approval pathways to accelerate patient access to therapies addressing unmet medical needs, particularly in oncology and rare diseases. The European Medicines Agency (EMA) has introduced several such pathways; however, their efficiency compared to other global regulators remains a subject of evaluation. This systematic review aimed to evaluate regulatory drug approval pathways within the EMA and compare them with other regulated markets,… https://www.jrnls.org/ijpi/17/1/150 https://www.jrnls.org/ijpi/17/1/150 Mon, 01 Mar 2027 00:00:00 GMT Preet Tyagi, Satyam Rajput, Khushi Shrivastava, Sakshi Chaudhary, Aditya Vikram Jain, Preeti Yadav International Journal of Pharmaceutical Investigation Flame photometry is a sensitive technique for estimating alkali metals in pharmaceuticals and herbal extracts. It works on thermal excitation in a flame, causing desolvation, atomization, dissociation, and emission of light at characteristic wavelengths (589 nm for sodium and 766 nm for potassium). The emitted intensity is proportional to concentration. Calibration standards (200-600 µL) prepared from 1 g/L NaCl and KCl solutions showed non-linearity at higher concentrations due to… https://www.jrnls.org/ijpi/17/1/155 https://www.jrnls.org/ijpi/17/1/155 Fri, 01 Jan 2027 00:00:00 GMT Mohammed Arfath Mysore Ismail, Lokesh Panjini Gopal Krishna, Muhammed Nufaiz Khalid, Akhilesh Dubey, Manohar Mahadev International Journal of Pharmaceutical Investigation Phytosome technology has transformed the delivery of plant-based bioactives by effectively addressing issues such as poor solubility, instability, and limited oral absorption. Unlike traditional lipid carriers, phytosomes form molecular complexes with phospholipids and phytoconstituents, thereby enhancing their interaction with cell membranes and enhancing systemic exposure. This review highlights the growing importance of phytosomes as advanced delivery systems and explores future… https://www.jrnls.org/ijpi/17/1/168 https://www.jrnls.org/ijpi/17/1/168 Mon, 01 Mar 2027 00:00:00 GMT Harini Vinayagam, Ritikasri Venkatraju, Sneha Raja, Jayasutha Jayram, Sujatha Kuppusamy, Divya Varshini Natarajan, Rajeswari Jagadeesan, Janeviennygrace, Roshini Nivetha, Sudharshan Antony Raj, Nandhakumar Kannan, Sruthika Natarajan International Journal of Pharmaceutical Investigation Polycystic Ovarian Syndrome (PCOS) is a common endocrine disorder in women of reproductive age, with insulin resistance and hyperinsulinemia playing key roles in its development. Although metformin is widely used to improve insulin sensitivity, its gastrointestinal side effects have increased interest in alternative therapies such as Myo-Inositol (MI) and L-carnitine. This review compares the mechanisms, clinical efficacy, and safety of MI and L-carnitine in the management of hyperinsulinemic… https://www.jrnls.org/ijpi/17/1/177 https://www.jrnls.org/ijpi/17/1/177 Mon, 01 Mar 2027 00:00:00 GMT Yang Yang, Tiefeng Jin, Xiangshan Ren, Junjie Piao, Xianchun Zhou, Aihua Jin, Songnan Zhang, Zhenhua Lin International Journal of Pharmaceutical Investigation In the context of rapid transformations in healthcare systems and medical knowledge, contemporary medical education faces increasing demands to cultivate physicians who are not only clinically competent but also innovative and research-oriented. Nonetheless, ongoing problems, such as a lack of teaching resources, unequal training infrastructures, and inadequate opportunities to conduct research, continue to hinder the quality of medical talent development at the frontier and in the… https://www.jrnls.org/ijpi/17/1/189 https://www.jrnls.org/ijpi/17/1/189 Mon, 01 Mar 2027 00:00:00 GMT Yokesh Shanmugam, Sambasivam Gopinath, Bhagyashree Annadurai, Saroj Kumari Sanjay Kumar, Dharshini Jaisankar Hindumathi, Ramya Govindarajulu, Sam Jebaraj, Dravid Raghul, Aswini Sreenivasan, Maha Vidya Gnanamani, R Abdur Rahman, Kaniga Pandi International Journal of Pharmaceutical Investigation Proteolysis-Targeting Chimeras (PROTACs) have revolutionized small-molecule pharmacology by harnessing the ubiquitin-proteasome system to achieve catalytic, event-driven degradation of disease-associated proteins rather than transient inhibition. This approach has emerged as a promising therapeutic strategy for targeting conventionally druggable and previously undruggable proteins across multiple disease areas. This review critically appraises the evolution of PROTAC technology from its… https://www.jrnls.org/ijpi/17/1/207 https://www.jrnls.org/ijpi/17/1/207 Tue, 01 Dec 2026 00:00:00 GMT Hamza Kutty Pottengal, Prasanth Viswanadhan Vasantha, Rakeshkumar Jat International Journal of Pharmaceutical Investigation Background: The innovative analytical quantification of lupus medication Voclosporin was developed by HPLC, and HPTLC was abetted by the Ultra Violet spectroscopic method using the QbD approach. Materials and Methods: The Cary 5000 double-beam spectrophotometer was used to measure the UV absorbance. Chromatographic separation was performed in the Agilent C18 column with mobile phase consisting of different concentrations of Acetonitrile and phosphate buffer. Variables of the methods were… https://www.jrnls.org/ijpi/17/1/215 https://www.jrnls.org/ijpi/17/1/215 Tue, 01 Dec 2026 00:00:00 GMT Mehdi Fathima, Deepak Kumar Jha, Saroj Kumar Sah, Soham Bhattacharjee International Journal of Pharmaceutical Investigation Aim and Objectives: Around 20% of diabetic patients are at increased risk of chronic foot ulcers. Current treatments mainly focus on glycemic control and supportive care, with limited effectiveness. Mononuclear Cell (MNC) therapy, containing hematopoietic, mesenchymal, and progenitor cells, is emerging as a novel and effective regenerative approach for Diabetic Foot Ulcers (DFU). The objective of the study is to evaluate the safety profile and healing efficacy of MNC-based therapy in a diabetic… https://www.jrnls.org/ijpi/17/1/224 https://www.jrnls.org/ijpi/17/1/224 Tue, 01 Dec 2026 00:00:00 GMT Shaik Parveena Ferdhoz, Naga Srinivasa Reddy Durgempudi, Pavan Kumar Yanamadala, Ramya Athina, Hima Varshini Korrapati, Harish Kakani, Jyothika Mandava, Triveni Yeddu, Anjali Chokka, Rama Rao Nadendla, Pallavi Vadlamudi International Journal of Pharmaceutical Investigation Background: Non-Communicable Diseases (NCDs) are increasingly driven by lifestyle and occupational factors, particularly in academic environments where staff experience varying workloads, sedentary patterns, and role-specific stressors. Systematic health mapping can help identify early risk indicators and guide preventive interventions. Objectives: To map the health status of teaching and non-teaching staff using a multidimensional health-mapping tool and to analyse the relationship between… https://www.jrnls.org/ijpi/17/1/232 https://www.jrnls.org/ijpi/17/1/232 Mon, 01 Mar 2027 00:00:00 GMT Ramalingam Gomathi, Thirupambaram Nataraja Sundaram Uma Maheswari, Shanmugam Rajesh Kumar International Journal of Pharmaceutical Investigation Background: Chronic inflammation and oxidative stress lead to tissue damage, resulting in heightened interest in plant-based therapeutics with low toxicity. Sesame and raspberry contain bioactive compounds that are both anti-inflammatory and antioxidant. However, little research has been conducted on their combined formulation, particularly regarding cytotoxicity and biocompatibility. Aim: This study aimed to evaluate the molecular cytocompatibility and dose-dependent effects of a novel sesame… https://www.jrnls.org/ijpi/17/1/238 https://www.jrnls.org/ijpi/17/1/238 Mon, 01 Mar 2027 00:00:00 GMT Sonika Shrivastav, Kamal Singh Rathore, Dinesh Kumar Yadav, Phool Chandra, Arvind Raghav, Neetu Sachan International Journal of Pharmaceutical Investigation Background: Major depressive disorder is a heterogeneous disease that primarily contributes to global disability. In this condition, individuals often experience disturbances in sleep patterns and psychomotor functions, experiences of guilt, diminished self-worth, inclination towards self-harm, as well as dysfunctions in autonomic and gastrointestinal processes. Saraca asoca (Roxb.) De. wild commonly known as Sita Ashoka is a perennial plant, native to Central and East Himalaya and consists of… https://www.jrnls.org/ijpi/17/1/249 https://www.jrnls.org/ijpi/17/1/249 Mon, 01 Mar 2027 00:00:00 GMT Reddy Prasad Chowdareddy, Thirunavukkarasu Jayaraman, Afzal Khan AK, Mohanakrishna Ghanta, Bibi Umeza International Journal of Pharmaceutical Investigation Objectives: Pomegranate (Punica granatum) is a well-known source of bioactive phytochemicals, particularly punicalagin, which contributes to its antioxidant, anti-inflammatory, and antimicrobial properties. Materials and Methods: In this study, a robust High-Performance Thin-Layer Chromatography (HPTLC) method was developed to fingerprint and quantify punicalagin in aril juice. Results: The optimized mobile phase-chloroform: ethyl acetate: formic acid: methanol (4.0:5.2:0.6:0.2,… https://www.jrnls.org/ijpi/17/1/256 https://www.jrnls.org/ijpi/17/1/256 Tue, 01 Dec 2026 00:00:00 GMT Jitendra Kantilal Chordiya, Ujashkumar Shah, Nidhi Shah International Journal of Pharmaceutical Investigation Background: The Multi unit-controlled release dosage forms is a drug delivery system offering advantage over traditional monolithic controlled release system in achieving persistent and predictable drug delivery. Multiple unit dosage forms have advantages over single unit dosage form like more predictable gastric emptying, low intra or inter individual variability, lower risk of overdose and local irritation, gastric emptying less depend on nutritional status etc. Normally Multiple-Unit Dosage… https://www.jrnls.org/ijpi/17/1/269 https://www.jrnls.org/ijpi/17/1/269 Tue, 01 Dec 2026 00:00:00 GMT Jigneshkumar Varu, Pradeep Shahajirao Shindhe, Ramesh Shivappa Killedar, Aniket Ughade International Journal of Pharmaceutical Investigation Introduction: In Ayurveda, Allium sativum (Lashuna) has been described in great detail as a Medhya medication that may improve cognitive function. The current study used molecular docking and in silico network pharmacology to clarify the molecular mechanisms behind its neuroprotective function in Alzheimer's disease. Materials and Methods: Allium sativum phytochemicals were obtained from Dr. Duke's databases and IMPPAT 2.0. ADME and drug-likeness screening were then performed using SwissADME,… https://www.jrnls.org/ijpi/17/1/276 https://www.jrnls.org/ijpi/17/1/276 Tue, 01 Dec 2026 00:00:00 GMT Shalam Mohamed Hussain, Nayef Almutairi, Fahad Alrakaf, Mohammed Aljameli International Journal of Pharmaceutical Investigation Background: Alzheimer’s disease affecting about 18 million people world-wide. The socio-economic burden on world-economies costing more than 172 billion US $ annually for the US alone. Objectives: To prepare aqueous extract of T. foenum graecum seeds (FSE) to explore the possible treatment for cognitive deficit in experimental animals. Materials and Methods: FSE was subjected to preliminary phytochemical evaluation and antioxidant effect using free radical scavenging method (DPPH). All the… https://www.jrnls.org/ijpi/17/1/283 https://www.jrnls.org/ijpi/17/1/283 Tue, 01 Dec 2026 00:00:00 GMT Abhishek Pete Nagaraj, Purushotham Karadigere Nagaraju International Journal of Pharmaceutical Investigation Background: Epilepsy is a chronic neurological disorder characterized by recurrent seizures caused by abnormal electrical activity in the brain. The development of novel anticonvulsant agents with improved efficacy and safety remains a significant therapeutic challenge. This study aimed to evaluate imidazole derivatives as potential anticonvulsant candidates through comprehensive in silico ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis. Materials and Methods: A… https://www.jrnls.org/ijpi/17/1/292 https://www.jrnls.org/ijpi/17/1/292 Tue, 01 Dec 2026 00:00:00 GMT Tuba Türkoğlu, Semra Türkoğlu International Journal of Pharmaceutical Investigation Background: Verbascum diversifolium, an endemic medicinal plant native to Türkiye, is recognized for its potential therapeutic and economic value. This study aimed to evaluate the antimicrobial, antioxidant, total phenolic, and cytotoxic activities of its leaf and flower extracts. Materials and Methods: Antimicrobial activity was determined using the broth microdilution assay against three Gram-positive bacteria, three Gram-negative bacteria, and two fungal strains. Antioxidant activity was… https://www.jrnls.org/ijpi/17/1/300 https://www.jrnls.org/ijpi/17/1/300 Tue, 01 Dec 2026 00:00:00 GMT Yuanchao Kang, Shizhe Chen, Yanwen Hao, Yan Lin International Journal of Pharmaceutical Investigation Background: Adverse Drug Reactions (ADRs) severely affect clinical medication safety, and the Pareto principle is widely applied to identify key risk factors in pharmacovigilance. Systematic retrospective analysis of hospital ADR data helps clarify ADR distribution characteristics. Objectives: To analyze the epidemiological characteristics of ADRs in a single hospital and screen high-risk factors, so as to provide evidence for rational clinical medication and targeted ADR prevention. Materials… https://www.jrnls.org/ijpi/17/1/310 https://www.jrnls.org/ijpi/17/1/310 Tue, 01 Dec 2026 00:00:00 GMT Mitali Milind Bodhankar, Shrushti Soitkar, Snehal Shrivastav, Shubham Gupta, Pranali Band International Journal of Pharmaceutical Investigation Background/Objectives: Cutaneous candidiasis remains a significant clinical challenge, particularly in warm, moist body regions and immunocompromised individuals. This study focuses on the development and evaluation of a topical ethosomal gel of Voriconazole, a BCS Class II antifungal drug with poor aqueous solubility. Materials and Methods: Ethosomes, characterized by high ethanol content and lipid bilayers, were engineered to bypass the stratum corneum barrier. Seven formulations (F1-F7) were…