https://www.jrnls.org/jyp New articles published in Journal of Young Pharmacists. en Wed, 16 Sep 2026 00:00:00 GMT https://www.jrnls.org/jyp/18/3/611 https://www.jrnls.org/jyp/18/3/611 Wed, 16 Sep 2026 00:00:00 GMT Lingaraj Kariyaplar Marulasiddappa, Abhishek Pete Nagaraj, Purushotham Karadigere Nagaraju Journal of Young Pharmacists Tuberculosis (TB) growing prevalence of drug-resistant strains Mycobacterium tuberculosis, it continues to major worldwide disease and a major public health concern. Emergence of Extensively Drug-Resistant (XDR-TB), Multidrug-Resistant (MDR-TB) tuberculosis has confounded disease management globally and dramatically decreased the efficacy of traditional anti-tubercular therapy. Drug resistance mainly occurs through genetic mutations, improper drug usage, poor patient compliance, prolonged… https://www.jrnls.org/jyp/18/3/619 https://www.jrnls.org/jyp/18/3/619 Wed, 16 Sep 2026 00:00:00 GMT Rina Das, Swati Rana, Dinesh Kumar Mehta, Arush Sharma Journal of Young Pharmacists Menopause is characterized by a progressive decline in ovarian estrogen production, resulting in immune dysregulation and a chronic low-grade inflammatory state known as inflammaging. Beyond hormonal deficiency, emerging evidence highlights the role of the Estrobolome-the collection of gut microbial genes involved in estrogen metabolism-in regulating estrogen homeostasis and inflammatory responses. Disruption of the estrobolome may further exacerbate systemic inflammation and contribute to the… https://www.jrnls.org/jyp/18/3/626 https://www.jrnls.org/jyp/18/3/626 Wed, 16 Sep 2026 00:00:00 GMT Suraj Kumar, Pranita Jirvankar Journal of Young Pharmacists The BBB is one of the biggest challenges in the treatment of neurological diseases, as it blocks more than 98% of drugs reaching the brain. In this review, current nanotech approaches to overcoming the BBB are compiled, including functionalized NPs (liposomes, polymeric NPs, SLNs, and inorganic NPs) with different modifications for targeting, including RMT, CPPs, positive charges, and non-invasive methods of administration such as intranasal delivery and MRgFUS. In parallel, biomimetic systems… https://www.jrnls.org/jyp/18/3/639 https://www.jrnls.org/jyp/18/3/639 Wed, 16 Sep 2026 00:00:00 GMT Suriya Sundharesan, Sneha Raja, Reshma Suresh, Jayasutha Jayram, Sujatha Kuppusamy, Harini Vinayagam, Someshwaran Surendran, Tanmayee Paladugu Journal of Young Pharmacists Pharmacovigilance plays a key role in public health-it helps us spot, assess, and prevent adverse drug reactions throughout a drug’s life on the market. This review takes a closer look at how AI is reshaping pharmacovigilance. It covers what’s new in AI-driven tools, what global regulators think, where the technology stands now, and what hurdles still remain for drug safety monitoring. Review was conducted using peer-reviewed articles, regulatory reports, and official guidance from databases:… https://www.jrnls.org/jyp/18/3/646 https://www.jrnls.org/jyp/18/3/646 Wed, 16 Sep 2026 00:00:00 GMT Pankaj Sharma Journal of Young Pharmacists Ganoderma lucidum (Reishi) is a widely utilized medicinal mushroom in Asia, recognized for its hepatoprotective, antioxidant, immunomodulatory, and anticancer properties. The present review aims to systematically evaluate its cosmeceutical potential by examining bioactive composition, mechanistic dermatological effects, formulation strategies, and translational challenges. A comprehensive analysis of published in vitro, in vivo, and emerging clinical evidence was conducted, focusing on… https://www.jrnls.org/jyp/18/3/656 https://www.jrnls.org/jyp/18/3/656 Wed, 16 Sep 2026 00:00:00 GMT Sahana Shree Muthu, Shivasakthy Manivasakan, Vijayan Venugopal, Arumugam Muthuvel, David Livingstone Journal of Young Pharmacists Marine algae and their derivatives have gained substantial notice in the scientific community because of their rich source of bioactive compounds, which include carbohydrates, lipids, proteins, and pigments. These compounds have shown promising applications in both medical and dental sciences. A literature search (2000-2025) using PubMed, Scopus, and Google Scholar identified studies on marine algae bioactives, which were screened, extracted, and narratively synthesized for medical and dental… https://www.jrnls.org/jyp/18/3/662 https://www.jrnls.org/jyp/18/3/662 Wed, 16 Sep 2026 00:00:00 GMT Sanat Mahendra Dhoke, Mishthi Prajapati, Meensher Thapa Magar, Bipin Shaji Journal of Young Pharmacists Clozapine-Induced Myocarditis (CIM) is a rare but potentially life-threatening adverse drug reaction linked with the use of clozapine in treatment-resistant. The aim of this systematic review is to recognise the clinical features, diagnostic findings, and clozapine rechallenge outcomes. A systematic literature search was carried out according to the PRISMA 2020 guidelines using PubMed, Scopus, Web of Science and Google Scholar. Case reports published within the past 10 years were screened, and… https://www.jrnls.org/jyp/18/3/670 https://www.jrnls.org/jyp/18/3/670 Wed, 16 Sep 2026 00:00:00 GMT Gayatri Raveendran, Ramamurthy Murugan, Suruthi Kanaga Rathina, Priya B Krishnamoorthy, Shanmugapriya Ponnappan, G Senthilvel Journal of Young Pharmacists Diabetes Mellitus has become a global burden with features of hyperglycemia as a result of insulin resistance, impaired insulin secretion or both. Dietetics plays an important role in both the management and prevention of conditions like Diabetes. Traditional Indian System of medicine like Siddha emphasize Pathiyam or dietetics as a cornerstone in the management of Diabetes. This narrative review on Siddha dietetics was undertaken to explore and interpret the dietary principles prescribed for… https://www.jrnls.org/jyp/18/3/676 https://www.jrnls.org/jyp/18/3/676 Wed, 16 Sep 2026 00:00:00 GMT BS Sachin, Radhakrishnan Narayanaswamy, Anshu Kumar Yadav, Biswajit Das, V Shree Harsha, Kshama Nadig Journal of Young Pharmacists Circulating Brain-Derived Neurotrophic Factor (BDNF) has been proposed as a blood-based marker of synaptic vulnerability in Alzheimer’s Disease (AD), but published findings vary across disease stages and cohorts. This review and meta-analysis examined whether APOE ε4 carrier status modifies stage-dependent alterations in serum or plasma BDNF across the AD continuum. PubMed, Web of Science, Scopus, and Google Scholar were searched using terms for BDNF, Alzheimer’s disease or Mild Cognitive… https://www.jrnls.org/jyp/18/3/686 https://www.jrnls.org/jyp/18/3/686 Wed, 16 Sep 2026 00:00:00 GMT Pankaj Sharma Journal of Young Pharmacists Background Diabetes mellitus is a multifactorial metabolic disorder requiring multi-target therapeutic strategies. Medicinal plants rich in bioactive phytochemicals represent promising alternatives to conventional antidiabetic drugs. Gentiana kurroo, an endangered Himalayan herb, is traditionally used for metabolic and inflammatory disorders and contains compounds with potential glucose-lowering activity. Objectives This study aimed to evaluate phytochemicals from G. kurroo for antidiabetic… https://www.jrnls.org/jyp/18/3/693 https://www.jrnls.org/jyp/18/3/693 Wed, 16 Sep 2026 00:00:00 GMT Sharada Deore, Bhushan Arun Baviskar, Ram Chhatrapati Vighne Journal of Young Pharmacists Background Phytosomes overcome solubility, absorption, and stability limitations of crude extracts, leading to enhanced bioavailability, better therapeutic effect, and reduced required dose. Purpose Conventional Ayurvedic formulations of Centella asiatica and Bacopa monnieri are administered as churna or ghrita, requiring prolonged high doses that reduce compliance in geriatric patients due to swallowing difficulties and gastrointestinal intolerance. Phytosomal systems, inspired by ghrita… https://www.jrnls.org/jyp/18/3/702 https://www.jrnls.org/jyp/18/3/702 Wed, 16 Sep 2026 00:00:00 GMT Nuranis Syazwani Shaiful Hambry, Mohd Nizam Mordi, Shahrul Bariyah Sahul Hamid Journal of Young Pharmacists Background Hepatocellular Carcinoma (HCC) is a highly resilient cancer associated with poor survival outcomes. Current treatment with sorafenib inhibits Raf kinases but still encounter resistance mediated by alternative survival pathways. Caulerpa lentillifera (C. lentillifera) has demonstrated anti-cancer properties. Therefore, this study aims to assess its anticancer profile in hepatocellular carcinoma HepG2 cells and characterize the metabolomic profile of C. lentillifera hot water extract.… https://www.jrnls.org/jyp/18/3/709 https://www.jrnls.org/jyp/18/3/709 Wed, 16 Sep 2026 00:00:00 GMT Sagar D. Magar, Shubham P. Mankar, Sanket K. Tambe, Amol S. Dighe, Nilima M. Wani, Mayur S. Bhosale, Rahul K. Godge, Dattaprasad N. Vikhe, Jagdish R. Kudnar Journal of Young Pharmacists Background Breast cancer treatment with current dual CDK4/6 inhibitors is limited by hematological toxicity and acquired drug resistance. CDK6 is overexpressed in specific breast cancer subtypes and represents a validated molecular target for the development of new anticancer agents. This study aimed to design, synthesize, and evaluate novel spiropyran derivatives as putative CDK6-targeting anticancer agents for breast cancer treatment. Materials and Methods Eight spiropyran derivatives (S1-S8)… https://www.jrnls.org/jyp/18/3/720 https://www.jrnls.org/jyp/18/3/720 Wed, 16 Sep 2026 00:00:00 GMT Mohamed Ishal Manningapatt, Muralidharan Palayyan Journal of Young Pharmacists Objectives The current research was aimed to assess the antimicrobial activity and LC-MS characterization, and computational molecular analysis of the ethanolic extract of marine macro algae Sargassum tenerrimum J. Agardh. Materials and Methods Marine macro algae S. tenerrimum collected from the coastal sediment was shade-dried, ground into powder, extracted by soxhlation using ethanol as the solvent. The dried extract obtained underwent phytochemical assessment and evaluation of antimicrobial… https://www.jrnls.org/jyp/18/3/727 https://www.jrnls.org/jyp/18/3/727 Wed, 16 Sep 2026 00:00:00 GMT Kaniga Pandi, Binoy Varghese Cheriyan, Jayasri Bantaram, Indhumathi Jagan, Mahalakshmi Sundarraj, Subha Pradhaa Ramachandran, Preethi Harikrishnan, Sharmila Sakthisivanandhan, Arunpandiyan Jeyakumar, Inigo Pathuvairajan, Mathesvaran Thirunavukarasu, Bhavya Ekambaram Journal of Young Pharmacists Background Dental caries and periodontal diseases are among the most prevalent oral disorders worldwide, necessitating the development of safe and effective therapeutic approaches. Green-synthesized nanoparticles derived from medicinal plants offer enhanced biocompatibility and therapeutic potential. Hedyotis diffusa, a traditional medicinal herb with established antimicrobial and anti-inflammatory properties, represents a promising candidate for nanoparticle synthesis. Objectives This study… https://www.jrnls.org/jyp/18/3/741 https://www.jrnls.org/jyp/18/3/741 Wed, 01 Jul 2026 00:00:00 GMT Pooja Singh, Bhavna Kumar, Santosh Kumar Verma Journal of Young Pharmacists Background Tuberculosis treatment requires prolonged multidrug therapy, often associated with poor patient compliance and systemic side effects. The present study aimed to develop and optimize a Poloxamer 407-based thermosensitive nanoparticle-loaded in situ gel system for sustained pulmonary delivery of first-line anti-tubercular drugs. Materials and Methods Drug-loaded sodium alginate nanoparticles containing isoniazid, rifampicin, moxifloxacin HCl, and pyrazinamide were prepared by… https://www.jrnls.org/jyp/18/3/755 https://www.jrnls.org/jyp/18/3/755 Wed, 16 Sep 2026 00:00:00 GMT Koushik Yetukuri, Sethu Chandra Kanth Annavarapu, Venkata Jaswanth Balla, Vasudeva Bellana, Avinash Chowdary Chirumamilla, Siva Pradeep Raparla Journal of Young Pharmacists Background The design and optimization of a Tinospora cordifolia (Giloy) extract-loaded topical gel was carried out to explore its anti-inflammatory potential using a Box-Behnken Design (BBD). The study focused on improving formulation characteristics for effective topical delivery. Materials and Methods Three formulation variables-Carbopol 934 (A), triethanolamine (B), and propylene glycol (C) were optimized based on their effects on viscosity, retention time, and phenolic content. ATR-FTIR… https://www.jrnls.org/jyp/18/3/763 https://www.jrnls.org/jyp/18/3/763 Wed, 16 Sep 2026 00:00:00 GMT SVVNSM Lakshmi, S Dinesh Mohan, B Varsha, G Mythri, B Srimukhi Journal of Young Pharmacists Background Increasing safety concerns regarding synthetic colorants have promoted the development of herbal cosmetic formulations. Butea monosperma flowers are rich in natural pigments and bioactive compounds suitable for cosmetic use. Objectives The present study aimed to formulate and evaluate a herbal lipstick using the aqueous extract of Butea monosperma flowers as a natural colorant. Materials and Methods The extract was prepared by maceration and reflux extraction and incorporated into a… https://www.jrnls.org/jyp/18/3/770 https://www.jrnls.org/jyp/18/3/770 Wed, 16 Sep 2026 00:00:00 GMT Deepak Raja Arulmozhi, Pooja Sathishkumar, Subramanian Somaskanthan Journal of Young Pharmacists Background Diabetic Retinopathy (DR) and Diabetic Macular Edema (DME) require effective posterior segment drug delivery, challenged by ocular anatomical barriers. Triamcinolone Acetonide (TA) despite its intravitreal efficacy carries risks of elevated intraocular pressure and cataract formation. Folic Acid (FA) exhibits anti-angiogenic and anti-oxidant potential but suffers poor corneal permeability. Co-loaded liposomal systems offer a non-invasive strategy by encapsulating both hydrophilic and… https://www.jrnls.org/jyp/18/3/779 https://www.jrnls.org/jyp/18/3/779 Wed, 16 Sep 2026 00:00:00 GMT Baisnabdas Pathak, Saptarshi Samajdar, Deepshikha Datta, Bimal Das Journal of Young Pharmacists Background Polysaccharides from nature have attracted significant interest as biocompatible and eco-friendly polymers used as carriers in drug delivery systems. ZMBP, which stands for Ziziphus mauritiana fruit pulp polysaccharide, is an example of such polymers; nevertheless, it is crucial to optimize its formulation for effective release of drugs. The objective of this research was to formulate and optimize propranolol hydrochloride loaded on ZMBP based polymeric beads. Materials and Methods… https://www.jrnls.org/jyp/18/3/786 https://www.jrnls.org/jyp/18/3/786 Wed, 16 Sep 2026 00:00:00 GMT Mitali Milind Bodhankar, Steffi George, Pooja Nandlal Taori, Nayana Chirag Vora Journal of Young Pharmacists Background Vancomycin (VAN) is used as a model peptide. It has been used extensively to treat severe infections brought on by Gram-positive bacteria. Vancomycin in colon-targeting studies has its therapeutic relevance in treating colonic infections, particularly antibiotic-associated colitis caused by Clostridioides difficile. The use of polymers like Eudragit S100 enables pH-dependent release, protecting the drug in the small intestine and stomach while promoting release in the area of the… https://www.jrnls.org/jyp/18/3/795 https://www.jrnls.org/jyp/18/3/795 Wed, 16 Sep 2026 00:00:00 GMT Kaveri Guddada Siddabasappa, Laxman Sureshbabu Vijapur, Swati Setty, Ajay Kumar Oli, Apoorva Jain, Anita Ravi Desai Journal of Young Pharmacists Background Melatonin in situ gel was formulated and tested to use in the bony defects. Intrabony defects are clinical presentation in some periodontal disease. Materials and Methods In situ gel containing 0.1% w/v Melatonin and chitosan as polymer was formulated by cold method using different concentration of chitosan and beta glycerol phosphate. Based on gelling time and gelling capacity in situ gel was optimized for further evaluation. Evaluation of the product for appearance, pH, gelling… https://www.jrnls.org/jyp/18/3/801 https://www.jrnls.org/jyp/18/3/801 Wed, 01 Jul 2026 00:00:00 GMT C. A. SriRanjani, C. Asha Deepti, K. Bhavya Sri Journal of Young Pharmacists Objectives The increasing consumption of dietary protein supplements raises concerns regarding potential contamination and associated toxicological effects. The present study evaluates the cytotoxic and genotoxic potential of commercially available protein supplements using the Allium cepa root tip assay. Materials and Methods Six protein supplements originating from different geographical regions were evaluated. Cytotoxicity was determined by measuring root growth inhibition and calculating… https://www.jrnls.org/jyp/18/3/816 https://www.jrnls.org/jyp/18/3/816 Wed, 16 Sep 2026 00:00:00 GMT Manjunatha Pai Chennaithody, Rajesh Kaverikana Shankar, Manappa T Mandalamari, Abdul Fairoz Ahamed Journal of Young Pharmacists Background Depression is a multifactorial neuropsychiatric disorder involving multiple molecular targets and signalling pathways. Amoora rohituka has a variety of pharmacological properties but its antidepressant activity is still not explored. Hence, the antidepressant effect of A. rohituka was studied in an integrated systems pharmacology approach with a view to understanding the molecular mechanism behind it. Materials and Methods The reported phytoconstituents from the leaves of A. rohituka… https://www.jrnls.org/jyp/18/3/833 https://www.jrnls.org/jyp/18/3/833 Wed, 16 Sep 2026 00:00:00 GMT Shafqat Zaidi, Krishana Kumar Sharma Journal of Young Pharmacists Objectives Diabetic neuropathy is one of the major complications, which is characterized by chronic neuropathic pain, oxidative stress, and neuroinflammation related to diabetes. The current research is designed to assess the anti-neuropathic ability of resveratrol in Streptozotocin (STZ)-induced diabetic rats. Materials and Methods Male Wistar rats (220-280 g) were made diabetic by a single intraperitoneal injection of STZ (50 mg/kg). Rats (confirmed with hyperglycaemia) were fed resveratrol… https://www.jrnls.org/jyp/18/3/840 https://www.jrnls.org/jyp/18/3/840 Wed, 16 Sep 2026 00:00:00 GMT Rashed Mohammed Alghamdi Journal of Young Pharmacists Background CDK4 (303 amino acids) is a serine/threonine kinase that regulates the G1-S transition and which is dysregulated in oncogenesis, and thus is an important target of kinase therapeutics. Structural Profiling aids in understanding conformational stability, inhibitor binding and resistance. Purpose To conduct a brief in silico analysis of the kinase domain of CDK4 (Cyclin-dependent kinase 4, focusing on structure and conformational changes to guide therapeutics and structure-based drug… https://www.jrnls.org/jyp/18/3/850 https://www.jrnls.org/jyp/18/3/850 Wed, 16 Sep 2026 00:00:00 GMT Sankamithra Sankar, Lavanya Baskaran, Uma Arumbuliyur Natarajan, Mithun Kumar Journal of Young Pharmacists Background Preoperative anxiety is common and may impede surgical recovery, yet it is seldom addressed in routine peri-operative care. Materials and Methods The sample consisted of 100 adult patients (mean age 39.1±12.5 years, 56% females) undergoing surgical procedures at VIMS Hospital, Salem. The type of anaesthesia used comprised general (28%), regional (20%) and local (52%) anaesthesia. Amsterdam Preoperative Anxiety and Information Scale (APAIS) and Quality of Recovery-40 (QoR-40) scores… https://www.jrnls.org/jyp/18/3/855 https://www.jrnls.org/jyp/18/3/855 Wed, 16 Sep 2026 00:00:00 GMT Sayali Motghare, Tanvi Thakare, Anamika Pramod Bhoyar, Sampada Patwardhan, Komal Nawale Journal of Young Pharmacists Background Fluconazole is a triazole antifungal extensively indicated for the treatment of Candida infections, particularly in hospitalized and immunocompromised patients. It exerts its action by inhibiting lanosterol 14-demethylase, thereby disrupting ergosterol synthesis and fungal cell membrane integrity. However, its widespread and prolonged use has contributed to the emergence of resistance, especially among non-albicans Candida species. Objectives This underscores the importance of… https://www.jrnls.org/jyp/18/3/862 https://www.jrnls.org/jyp/18/3/862 Wed, 16 Sep 2026 00:00:00 GMT Punam Kela, Sakshi Latey, Karishma Mainkar, Shreyasi Banerjee, Pratiksha Kulkarni, Nikhil Sathaye Journal of Young Pharmacists Background Food-Drug Interactions (FDIs) can lead to significant changes in drug efficacy and safety and may result in therapeutic failure. Inadequate knowledge and awareness of FDIs among Healthcare Professionals (HCPs) and patients can further increase the risk of such interactions. Therefore, the present study aimed to assess the awareness and knowledge of FDIs among patients and HCPs and to identify the demographic and professional factors associated with their knowledge levels. Materials… https://www.jrnls.org/jyp/18/3/870 https://www.jrnls.org/jyp/18/3/870 Wed, 16 Sep 2026 00:00:00 GMT Ayush Khandelwal, Trishala Gurung, Kanishaka Kapoor, Aashish Kumar, Rishabh Chaudhary, Ashwani K Sood, Sumeet Gupta, Rupa Joshi, Seema Bansal Journal of Young Pharmacists Background and Aim Infants and children are especially susceptible to medication errors due to their recurrent illnesses and unique physiological traits. This underscores the significance of rational and evidence-based prescribing in paediatric care. Materials and Methods This study examined 730 paediatric prescriptions from outpatient and inpatient departments at the MM Institute of Medical Sciences and Research over a period of five months, utilising World Health Organisation (WHO) core drug…