https://www.jrnls.org/lsrc New articles published in Life Science Research Communications. en Thu, 01 Jan 2026 00:00:00 GMT https://www.jrnls.org/lsrc/2/3/161 https://www.jrnls.org/lsrc/2/3/161 Thu, 01 Jan 2026 00:00:00 GMT Abhishek Kumar, Kiran Dobhal, Parul Bisht, Sayantan Mukhopadhyay Life Science Research Communications H3N2 influenza viruses are among the prevalent strains causing seasonal flu in humans. While respiratory symptoms have been the hallmark of influenza infections, neurological complications such as encephalopathy associated with H3N2 viruses have garnered attention due to their severity and implications for affected individuals. The pathogenesis of H3N2-induced encephalopathy involves multifaceted mechanisms, including direct viral invasion, immune-mediated responses, and neuro-inflammatory… https://www.jrnls.org/lsrc/2/3/168 https://www.jrnls.org/lsrc/2/3/168 Thu, 01 Jan 2026 00:00:00 GMT Murali G, K.V. Giriraj, Kiran N, Roshan Manoharan, Anil Dhakal Life Science Research Communications Brand name prescribing remains common in clinical practice despite the widespread availability of therapeutically equivalent generic medicines. Although generic medications undergo rigorous regulatory evaluation for bioequivalence and offer substantial cost advantages, both physicians and patients frequently demonstrate a preference for branded products. This preference is influenced by physician familiarity, pharmaceutical marketing, institutional prescribing culture, perceived quality… https://www.jrnls.org/lsrc/2/3/182 https://www.jrnls.org/lsrc/2/3/182 Thu, 01 Jan 2026 00:00:00 GMT Abhinav Saini, Rohit Chandel, Anju Bala Life Science Research Communications The innovative Novel Drug Delivery System (NDDS) known as nanoemulsions provide the ability of controlled or regulated drug release, biologically active ingredients, and genetical material. A nanoemulsion is an oily, a surfactant, and a hydrophilic phase, which is a thermodynamically or kinetically stable liquid solution that is optically clear and typically has droplet diameters between 10 and 500 nm. The goal of this study is to create and characterise the best suitable nano-emulsion drug… https://www.jrnls.org/lsrc/2/3/193 https://www.jrnls.org/lsrc/2/3/193 Thu, 01 Jan 2026 00:00:00 GMT Anil Dhakal, Chaitra Chandran, Roshan Manoharan Life Science Research Communications Pharmacogenomics has emerged as a cornerstone of precision medicine by providing insights into how inherited genetic variations influence individual responses to drug therapy. Genetic polymorphisms affecting drug-metabolizing enzymes, transporters, receptors, and signalling pathways contribute significantly to interindividual variability in drug efficacy, toxicity, and therapeutic outcomes. Over the past two decades, advances in molecular genetics, high-throughput sequencing technologies, and… https://www.jrnls.org/lsrc/2/3/206 https://www.jrnls.org/lsrc/2/3/206 Thu, 01 Jan 2026 00:00:00 GMT Shashank Sharma, Rupali Sontakke, Sanjay Jain Life Science Research Communications The decline of brain functions due to the neurodegenerative process occurring over time with aging is often referred to as Alzheimer's Disease (AD). This gradual breakdown of brain tissue is responsible for the greater incidence of dementia and diminished capacity for thinking as adults age. The continued research in this field has been complicated by the fact that pathological changes in the brain frequently occur long before clinical symptoms are present. With advances in both AI and… https://www.jrnls.org/lsrc/2/3/222 https://www.jrnls.org/lsrc/2/3/222 Thu, 01 Jan 2026 00:00:00 GMT Praveen Kumar Ashok, B Babita, Vartika Lohani, Reetika Gupta, Jhuma Samanta, Kumud Upadhyaya Life Science Research Communications Phenolic compounds are important secondary metabolites found widely in medicinal plants. They include phenolic acids, flavonoids, tannins, stilbenes, lignans, coumarins, and related compounds. These compounds have attracted considerable research interest because of their diverse biological properties. Their chemical structures influence their solubility, stability, antioxidant capacity, and biological activity. Medicinal plants provide a rich and natural source of these compounds. This review… https://www.jrnls.org/lsrc/2/3/244 https://www.jrnls.org/lsrc/2/3/244 Thu, 01 Jan 2026 00:00:00 GMT Sudarshan Rao Nagineni, Priyanka Yarra, Bhargavi Satya Addala Life Science Research Communications Population-level blood pressure control has hit a frustrating plateau over the past decade, and surprisingly, the bottleneck is seldom pharmacological potency-it is adherence. For the elderly, pediatric patients, and those with neurological or age-related swallowing difficulties, the mundane act of taking a daily tablet presents a genuine functional barrier that directly undermines treatment continuity. Orodispersible Tablets (ODTs), which dissolve on the tongue within seconds without water,… https://www.jrnls.org/lsrc/2/3/257 https://www.jrnls.org/lsrc/2/3/257 Thu, 01 Jan 2026 00:00:00 GMT Praveen Kumar Ashok, Jhuma Samanta, Meena Devi, Kanak Chauhan, Nisha Agari, Vartika Lohani, Amandeep Singh, Mohd Tasleem Life Science Research Communications Oral diseases such as dental plaque, gingivitis, and periodontal disorders remain important global public health concerns. Dental plaque is a structured microbial biofilm that plays a major role in gingival inflammation and periodontal tissue damage. This review evaluates the therapeutic potential of bioactive phytochemicals present in herbal mouthwashes for controlling oral biofilm and gingival inflammation. Published literature on medicinal plants, phytochemicals, oral pathogens, biofilm… https://www.jrnls.org/lsrc/2/2/75 https://www.jrnls.org/lsrc/2/2/75 Fri, 04 Sep 2026 00:00:00 GMT Atul Sharma, Sonika Rattan, Nitika Sharma, Sharad S Life Science Research Communications Artificial Intelligence (AI) is a tool for data analysis and data related problems. This advancement has led to several technological achievements in virtually all fields from engineering to architecture, education, accounting, business, health, and many more. Intelligent modeling is the main goal of Artificial Intelligence (AI), which aids with knowledge envisioning, problem solving, and decision making. AI has recently become significant in a number of pharmacy-related domains, including… https://www.jrnls.org/lsrc/2/2/83 https://www.jrnls.org/lsrc/2/2/83 Fri, 04 Sep 2026 00:00:00 GMT Potnuru Sai Sudheer, S Sushma, Sadhu Joshika, Panatala Devi, M G Pavani, Unnam Mokshith, Jamal Basha D Life Science Research Communications Healthcare systems worldwide encompass both traditional and contemporary medical practices. Ayurveda, an ancient Indian system of medicine, emphasizes individualized treatment, disease prevention, and restoration of physiological balance through herbal medicines, dietary regulation, lifestyle modification, and detoxification procedures. In contrast, contemporary allopathic medicine is founded on evidence-based scientific principles and utilizes pharmacological agents, advanced diagnostics, and… https://www.jrnls.org/lsrc/2/2/101 https://www.jrnls.org/lsrc/2/2/101 Fri, 04 Sep 2026 00:00:00 GMT Gade Navya Life Science Research Communications Pharmaceutical research is changing the world. Scientific advancements over decades have led to new molecular entities; however, the costs of developing them have increased to over 2.6 billion, and only 12% of Phase I chemical entities obtain regulatory approval. The recent emergence of artificial intelligence as a computational paradigm is good because it provides a tool set to address inefficiencies in drug research paradigm. This critical review covers AI applications in drug delivery… https://www.jrnls.org/lsrc/2/2/110 https://www.jrnls.org/lsrc/2/2/110 Fri, 04 Sep 2026 00:00:00 GMT Maaz Reza, Aakil Iqbal Ganai, Tawqeer Shafi, Shafkat Hussain Malik Life Science Research Communications Artificial Intelligence (AI) has emerged as a transformative technology reshaping pharmacovigilance (PV)-the science and activities relating to the detection, assessment, understanding, and prevention of Adverse Drug Reactions (ADRs). Traditional PV systems, which rely heavily on manual data entry, coding, and case assessment, are increasingly challenged by the rapid growth of real-world data sources such as Electronic Health Records (EHRs), literature databases, social media, and spontaneous… https://www.jrnls.org/lsrc/2/2/118 https://www.jrnls.org/lsrc/2/2/118 Fri, 04 Sep 2026 00:00:00 GMT Khaled Sufyan Shaheen Life Science Research Communications Neurological and psychiatric disorders, particularly anxiety, depression, and sleep disturbances, represent global health challenges. This comprehensive review evaluates the phytotherapeutic potential, neuropharmacological mechanisms, and clinical outcomes of Valeriana officinalis (Valerian) and Hypericum perforatum (St. John's Wort). Valerian primarily modulates the GABAergic system through valerenic acid, acting as a safe alternative for insomnia and mild anxiety. Conversely, St. John's Wort… https://www.jrnls.org/lsrc/2/2/123 https://www.jrnls.org/lsrc/2/2/123 Fri, 04 Sep 2026 00:00:00 GMT Muhammad Shaheer Life Science Research Communications Upper Respiratory Tract Infections are among the most common conditions encountered in primary care and community healthcare settings particularly in developing countries such as Pakistan. Most URTIs are of viral origin and are self-limiting requiring only symptomatic management rather than antibiotic therapy. Despite this, antibiotics, particularly Azithromycin, are frequently used inappropriately for URTIs in Pakistan. Easy access to antibiotics through community pharmacies and drug stores,… https://www.jrnls.org/lsrc/2/2/127 https://www.jrnls.org/lsrc/2/2/127 Fri, 04 Sep 2026 00:00:00 GMT Arshi Kaushik Life Science Research Communications Medicinal chemistry has moved rapidly from treating computational drug design, ADMET prediction, and precision medicine as separate strands to integrating them within a single discovery pipeline, yet most existing reviews still address these developments in isolation. This review addresses that gap by tracing the complete drug development trajectory, from target identification through lead discovery, preclinical evaluation, and clinical translation, with attention to the technologies reshaping… https://www.jrnls.org/lsrc/2/2/139 https://www.jrnls.org/lsrc/2/2/139 Fri, 04 Sep 2026 00:00:00 GMT Mueen Ahmed K. K, Mohammed Yunus Life Science Research Communications Global agriculture faces simultaneous pressure to raise productivity, adapt to a changing climate, and restore degraded natural resources, giving rise to three overlapping paradigms-climate-smart agriculture, regenerative agriculture, and agroecology-that share the ambition of reconciling yield with resilience. Despite a rapidly expanding literature, empirical evidence remains fragmented across crop, livestock, socioeconomic, and natural-resource subsystems, limiting the capacity of… https://www.jrnls.org/lsrc/2/2/151 https://www.jrnls.org/lsrc/2/2/151 Fri, 04 Sep 2026 00:00:00 GMT Mueen Ahmed K. K, Mohammed Yunus Life Science Research Communications Vitamin D metabolites regulate antimicrobial peptide expression in the respiratory epithelium, providing a biological rationale for supplementation as a means of preventing Acute Respiratory Infections (ARIs). Observational data have consistently linked low circulating 25-Hydroxyvitamin D (25[OH]D) with greater infection risk, but trial results have been heterogeneous. To synthesize randomized evidence on whether Vitamin D supplementation reduces ARI risk, and to characterize the factors that… https://www.jrnls.org/lsrc/2/2/158 https://www.jrnls.org/lsrc/2/2/158 Fri, 04 Sep 2026 00:00:00 GMT Briti Deb Life Science Research Communications Drugsideeffect is a Python package for exploratory pharmacovigilance using unstructured health-related text. It differs from general-purpose NLP libraries by integrating supervised filtering, symptom lexicons, slang normalization, temporal expression extraction, alert keyword detection, sentiment analysis, and visualization into a single workflow specifically designed for exploratory pharmacovigilance. Informal user-generated narratives are transformed into structured drug-related signals for… https://www.jrnls.org/lsrc/2/1/1 https://www.jrnls.org/lsrc/2/1/1 Wed, 15 Jul 2026 00:00:00 GMT Nisaruddin Ansaruddin, Sanskruti S. Khalokar, Achal D. Agrawal, Sakshi S. Bele, Suraj K. Yadav, Nitin B. Kohale, Harigopal S. Sawarkar Life Science Research Communications One area that nanotechnology has benefited the modern medicine is in the field of surgery advancement in the Drug Delivery Systems (DDS). Nanocarriers make targeted, controlled, and effective administration of therapeutic agents, and hence, improved efficacy and reduced side effects. This review addresses the different varieties of nanocarriers, their action mechanisms, and use in different medical disciplines, and the problems of clinical translation. We put emphasis on future and recent… https://www.jrnls.org/lsrc/2/1/7 https://www.jrnls.org/lsrc/2/1/7 Wed, 15 Jul 2026 00:00:00 GMT Pragati Jain, Anurag Verma, Ashish Kumar Gupta Life Science Research Communications Artificial Intelligence (AI) is transforming healthcare by enabling personalized support, digital therapeutics, and intelligent health management tools. From diabetes management applications to AI-powered medical chatbots, these technologies are increasingly influencing healthcare decisions. Despite rapid market growth, with the global AI healthcare market projected to exceed USD 110 billion by 2030, consumer adoption remains limited. A major factor underlying this hesitation is trust. This… https://www.jrnls.org/lsrc/2/1/26 https://www.jrnls.org/lsrc/2/1/26 Wed, 15 Jul 2026 00:00:00 GMT Harsh Mishra, Ridhi Ridhi Life Science Research Communications Gout, a chronic inflammatory arthritis driven by hyperuricemia and monosodium urate crystal deposition, remains a significant clinical challenge due to limitations in current pharmacological therapies, including adverse effects and poor patient compliance. Curcumin, a natural polyphenol derived from Curcuma longa, exhibits potent anti-inflammatory and antioxidant properties with potential therapeutic implications for gout. However, its clinical translation is hindered by poor solubility, low… https://www.jrnls.org/lsrc/2/1/40 https://www.jrnls.org/lsrc/2/1/40 Wed, 15 Jul 2026 00:00:00 GMT Swarnim Swati* Life Science Research Communications Drug repurposing, also called drug repositioning, has become a new and effective way to find and develop new drugs. It means finding new ways to use existing or already approved drugs that were made for other diseases. It usually takes more than 10 to 15 years and a lot of money to get a drug to market using the traditional drug development process. Many drug candidates also fail during clinical trials because of problems with safety, effectiveness, or toxicity. Drug repurposing is a promising… https://www.jrnls.org/lsrc/2/1/44 https://www.jrnls.org/lsrc/2/1/44 Wed, 15 Jul 2026 00:00:00 GMT Aanshi Rikin Patel, Akash P Mathuria Life Science Research Communications Background: Medication knowledge and adherence in post-cataract surgery patients is crucial for optimal recovery. Objectives: To compare the effectiveness of verbal counselling, clinic-based pictogram demonstration and take-home pictogram education on medication knowledge and adherence in post-cataract surgery patients. Materials and Methods: A randomised, parallel-group, controlled trial was conducted in 150 cataract surgery patients. They were equally enrolled in three different experimental… https://www.jrnls.org/lsrc/2/1/55 https://www.jrnls.org/lsrc/2/1/55 Wed, 15 Jul 2026 00:00:00 GMT Hamid Ismail Hamid Edris, Moghal Habiba Maheen, Mukesh Kumar, Diwakar Kumar Sarraf, Rabin Das Life Science Research Communications Background: Vitamin D deficiency is a well-documented yet frequently overlooked public health concern among postmenopausal women, particularly in low- and middle-income countries where diagnostic resources and health literacy remain limited. Objectives: This study sought to assess the level of knowledge, degree of awareness, and prevailing lifestyle practices concerning Vitamin D deficiency among postmenopausal women attending a tertiary-care setting in Visakhapatnam, India. Materials and… https://www.jrnls.org/lsrc/2/1/59 https://www.jrnls.org/lsrc/2/1/59 Wed, 15 Jul 2026 00:00:00 GMT Rahul Nimba Patil, Harshada Milind Jadhav, Ajay Jantar Pawara, Harish Sandesh Khairnar, Snehal Popat Bodke, Anushka Bajirao Rajole Life Science Research Communications Background: Peptic ulcer disease is a common gastrointestinal disorder resulting from an imbalance between aggressive factors such as gastric acid and defensive mechanisms of the gastric mucosa. Medicinal plants are widely explored as potential sources of safer antiulcer agents. The present study aimed to investigate the in vitro antiulcerogenic activity of Ricinus communis L. leaf extract. Materials and Methods: The antiulcer potential of the extract was evaluated using H⁺/K⁺-ATPase inhibition… https://www.jrnls.org/lsrc/2/1/65 https://www.jrnls.org/lsrc/2/1/65 Wed, 15 Jul 2026 00:00:00 GMT Sreedevi M, Vishnu Unnikrishnan, Devika Nair, Anaswara Anil, Narmadha M P, Aneesh T P, M K Unnikrishnan, Praveen G Pai Life Science Research Communications Background: Affordable access to essential medicines being a major challenge in low- and middle-income countries, India has introduced affordable generics named Janaushadhi. Although branded formulations dominate the market, cost-effective alternatives while improving accessibility, raises concerns of quality and clinical performance among healthcare professionals and patients. Objectives: To compare the pharmaceutical quality attributes and exploratory plasma drug levels of branded and… https://www.jrnls.org/lsrc/2/1/73 https://www.jrnls.org/lsrc/2/1/73 Wed, 15 Jul 2026 00:00:00 GMT Mueen Ahmed KK* Life Science Research Communications Large randomized trials of isolated antioxidant compounds have repeatedly returned null or adverse results, even as whole-food dietary patterns rich in the same compounds remain associated with better health. I write to suggest that this is not a paradox but a predictable consequence of a recurring design choice: testing single high-dose nutrients in isolation. https://www.jrnls.org/lsrc/2/1/74 https://www.jrnls.org/lsrc/2/1/74 Wed, 15 Jul 2026 00:00:00 GMT Mueen Ahmed KK* Life Science Research Communications Total antioxidant capacity (TAC) assays—FRAP, ORAC, TEAC, and their relatives—remain widely used to characterize foods and biological samples, and TAC values frequently appear in nutrition research and on product marketing. I write to caution against over-interpreting them, because their connection to in vivo biology is weaker than their popularity suggests. https://www.jrnls.org/lsrc/1/3/86 https://www.jrnls.org/lsrc/1/3/86 Mon, 01 Sep 2025 00:00:00 GMT Ahmed Hosny Hassan Life Science Research Communications Introduction the current epidemic of COVID-19 requires a lot of efforts to be controlled involving pharmacotherapy and clinical pharmacology studies. Aim: to introduce a brief review of drugs under investigation for COVID-19. Methodology Our project is a systematic review of many medications being studied for their effectiveness and safety in COVID-19 management. Results Antiviral drugs (osletmivir, ramdisvir), corticosteroids (dexamethasone), immunomodulators (anakinera, toculizumab),… https://www.jrnls.org/lsrc/1/3/99 https://www.jrnls.org/lsrc/1/3/99 Mon, 01 Sep 2025 00:00:00 GMT Toyiba Ibrahim, Mohd Afsahul Kalam, Sana Bila Suhail Life Science Research Communications The concept of tonics has been cornerstone of various systems of traditional medicine, serving as agents that restore vitality, enhance resilience, and promote overall well-being. In modern biomedicine, related concepts are explored under terms such as adaptogens, immunomodulators, and organ-supportive therapies, yet these approaches often remain fragmented and lack the integrative orientation found in traditional systems. Within Unani medicine, Muqawwiyat are deeply embedded in the…