https://www.jrnls.org/phm New articles published in Pharmacognosy Magazine. en Thu, 01 Jan 2026 00:00:00 GMT https://www.jrnls.org/phm/22/4/1231 https://www.jrnls.org/phm/22/4/1231 Thu, 01 Jan 2026 00:00:00 GMT Chen Liang, Xu Xiao-Qin, Guo Wen-Hui, Mai Di-Na Pharmacognosy Magazine Anchusa italica Retz., a botanical drug belonging to the Anchusa genus of the Boraginaceae family, is a traditional Chinese botanical drug and medicine widely used in Uygur medicine for treating palpitations, insomnia, neurasthenia, hypertension, and other disorders. Recent studies have revealed its diverse chemical constituents and expanded pharmacological understanding. The plant is abundant in oils, triterpenoids, flavonoids, and other bioactive metabolites. Modern pharmacological research… https://www.jrnls.org/phm/22/4/1246 https://www.jrnls.org/phm/22/4/1246 Thu, 01 Jan 2026 00:00:00 GMT Fan-Bin Kong, Jian-Hua Liu Pharmacognosy Magazine Background: Citral is a bioactive compound found in lemongrass oil. It functions as an antioxidant and possesses anti-inflammatory qualities. Objectives: The purpose of this study was to assess the anti-arthritic benefits of citral using a rat model with an adjuvant arthritis paradigm. Experimental Procedures: In Swiss Albino Wistar rats, arthritis was produced by intradermal injection of Freund’s adjuvant (0.1 mL) into their hind paw. Arthritic animals were given citral orally for a duration… https://www.jrnls.org/phm/22/4/1257 https://www.jrnls.org/phm/22/4/1257 Thu, 01 Jan 2026 00:00:00 GMT Xin Pang, Yuan Tian, Shasha Du, Jinyu Liu, Feimei Wang Pharmacognosy Magazine Background: Drug-induced liver toxicity is a major clinical challenge, being the primary cause of abrupt liver failure. This condition is intensified by an older population that consumes more drugs and the increasing hazards associated with unknown drug consumption. Objectives: This work was undertaken to study the beneficial values of ligustilide against acetaminophen-induced liver damage in rats. Materials and Methods: The experimental rats were administered 640 mg/kg of acetaminophen to… https://www.jrnls.org/phm/22/4/1269 https://www.jrnls.org/phm/22/4/1269 Thu, 01 Jan 2026 00:00:00 GMT Dan Zhou, Zehan Zhang, Zhilin Chen, Jianxing Zhang, Chao Pei Pharmacognosy Magazine Background: Oral lichen planus (OLP) is a prevalent chronic inflammatory oral mucosal disease with an uncertain pathogenesis and limited treatment options. Objectives: This study aimed to systematically explore the underlying therapeutic mechanisms of baicalein in the treatment of OLP using network pharmacology and single-cell RNA sequencing analysis. Materials and Methods: Baicalein target genes were sourced from the Comparative Toxicogenomics Database, SwissTargetPrediction, PharmMapper… https://www.jrnls.org/phm/22/4/1281 https://www.jrnls.org/phm/22/4/1281 Thu, 01 Jan 2026 00:00:00 GMT Jian Deng, Zongyao Duan, Hao Deng, Lu Ye Pharmacognosy Magazine Background: Psoralen is a biomaterial that promotes bone growth and repair and has been widely used in clinical orthopedic surgeries. Objectives: This study aims to explore the role and mechanism of polydopamine nanoparticle-encapsulated psoralen (PSO/PDA NPs) in the recovery of motor function after spinal cord compression. Materials and Methods: A Compressive Spinal Cord Injury (CSCI) rat model was constructed to explore the effects of PDA NPs and PSO/PDA NPs on spinal cord compression, and… https://www.jrnls.org/phm/22/4/1291 https://www.jrnls.org/phm/22/4/1291 Thu, 01 Jan 2026 00:00:00 GMT Yanli Wang, Fen Xie, Ying Cai, Ping Xiang Pharmacognosy Magazine Background: The proliferation of myeloma cells could be affected partly by the interaction between microRNA-29b (miR-29b) and Hedgehog. Objectives: The research on the mechanism of microenvironment of myeloma being restored by allicin, regulating the activity of Hedgehog pathway through miR-29b, was studied to develop theoretical evidence on the drug discovery for myeloma. Materials and Methods: A model of mice with myeloma was established. They were divided into several groups, including a… https://www.jrnls.org/phm/22/4/1301 https://www.jrnls.org/phm/22/4/1301 Thu, 01 Jan 2026 00:00:00 GMT Xiang Zhu, Shuang Zheng, Dengke Li, Ying Yang, Jinrong Zhao Pharmacognosy Magazine Background: Bone defects resulting from trauma or lesions are common orthopedic conditions that challenge bone regeneration. Bone mesenchymal stem cells (BMSCs) have garnered attention due to their osteogenic potential. Icariin has shown promise in promoting osteogenic and angiogenic differentiation in BMSCs through pathways such as BMP, MAPK, and Wnt/β- catenin. However, the optimal concentration of icariin and its dual osteogenic and angiogenic roles remain unclear. Objectives: This study was… https://www.jrnls.org/phm/22/4/1310 https://www.jrnls.org/phm/22/4/1310 Thu, 01 Jan 2026 00:00:00 GMT Chengcheng Xu, Shaoqi Chen, Yaning Bo, Qi Gui Pharmacognosy Magazine Background: Dehydrokoline has a wide range of pharmacological activities and exhibits anti-tumor potential effects in a variety of cancer types. Whether it plays a role in gastric cancer remains unclear. Objectives: This study aims to explore the mechanism by which liposome nanoparticles (Harmine NPs) coated with “dehydrocardamine” inhibit COX-2 expression by regulating the PTEN/Akt signaling pathway, thereby alleviating the inflammatory response in mice with gastric cancer and providing a new… https://www.jrnls.org/phm/22/4/1321 https://www.jrnls.org/phm/22/4/1321 Thu, 01 Jan 2026 00:00:00 GMT Dandan Wei, Lei Zhao Pharmacognosy Magazine Background: Curcumin has antioxidant and anti-myocardial ischemic effects, but its low water solubility and bioavailability limit clinical application. Objectives: This study aims to explore whether curcumin-loaded ferric oxide nanoparticles alleviate hypoxic injury in myocardial infarction. Materials and Methods: Preparation of ferric oxide (Fe3O4) nanoparticle-loaded curcumin complex. A cardiomyocyte hypoxia model was established using ligation surgery. The complex, Fe3O4 nanoparticles, and… https://www.jrnls.org/phm/22/4/1334 https://www.jrnls.org/phm/22/4/1334 Thu, 01 Jan 2026 00:00:00 GMT Xiaoling Li, Liye Hu Pharmacognosy Magazine Objectives: Linagliptin reduces blood glucose levels, but its efficacy in brittle diabetes mellitus with early diabetic nephropathy (BDM-EDN) remains unclear. Therefore, this study investigated the efficacy and safety of linagliptin in BDM-EDN treated with Dendrobium polysaccharide extract. Materials and Methods: From January 2020 to December 2022, 90 BDM-EDN patients admitted to the endocrinology department of our hospital were selected and equally divided into a control group, a Dendrobium… https://www.jrnls.org/phm/22/4/1345 https://www.jrnls.org/phm/22/4/1345 Thu, 01 Jan 2026 00:00:00 GMT Hyomin Lim, Yookyung Kim, Woo-Jae Park Pharmacognosy Magazine Background: Cadmium is a hepatotoxic heavy metal. Cadmium is known to induce ceramide generation and ferroptosis. Edible insects have recently been touted as a potential functional food. Various studies are being conducted in this regard. Objectives: This study was designed to investigate whether two types of insects, Tenebrio molitor larvae (TM) and Protaetia brevitarsis larvae (PB), can inhibit cadmium-induced hepatotoxicity. Materials and Methods: TM and PB powder were extracted using 70%… https://www.jrnls.org/phm/22/4/1356 https://www.jrnls.org/phm/22/4/1356 Thu, 01 Jan 2026 00:00:00 GMT Min Sun, Shengju Wu, Guozhen Yi, Li Yu Pharmacognosy Magazine Background: Chemotherapy targets rapidly dividing cells, impacting HSCs and hematopoiesis. Objectives: We evaluated the protective impacts of Althaea officinalis L. extract (AOE) against cyclophosphamide (CP)- related immunosuppression and damage to the spleen and bone marrow (BM) in rats. Materials and Methods: Sixty Wistar rats were assigned to six groups: a sham group receiving saline, a CP group receiving 100 mg/kg CP for 10 days, co-treatment groups receiving CP and AOE at doses of 250,… https://www.jrnls.org/phm/22/4/1371 https://www.jrnls.org/phm/22/4/1371 Thu, 01 Jan 2026 00:00:00 GMT Yuduo Wang, Xuezhen Ma Pharmacognosy Magazine Background: Chonglou saponin has been found to have certain tumor suppressor effects in a variety of cancers. However, Chonglou saponin has certain limitations and side effects in clinical application. Therefore, exploring new therapeutic strategies and mechanisms of action of Chonglou saponin is key for the treatment of esophageal cancer. Objectives: This study explored the mechanism by which mesoporous silica (MSNs)-mediated saponin inhibits the growth of esophageal cancer cells through… https://www.jrnls.org/phm/22/4/1381 https://www.jrnls.org/phm/22/4/1381 Thu, 01 Jan 2026 00:00:00 GMT He Jing, Fuxian Wei, Yan Wang Pharmacognosy Magazine Background: Ventricular arrhythmias (VAs) frequently arise as complications in chronic ischemic heart failure (CIHF). Objectives: We evaluated the effectiveness of resveratrol (RES) in a CIHF-induced rat model of VAs and explored the underlying mechanisms. Materials and Methods: Animals received the left anterior descending coronary artery ligation to simulate CIHF and were subsequently treated daily with RES for 2 months. The subjects were categorized into five groups: normal control, VAs… https://www.jrnls.org/phm/22/4/1391 https://www.jrnls.org/phm/22/4/1391 Thu, 01 Jan 2026 00:00:00 GMT Xiaoyan Wang, Zheng Liu Pharmacognosy Magazine Background: When the endometrium matures in step with the required morphological changes, blastocyst implantation occurs more effectively. Objectives: The present study aimed to examine the reproductive toxicity of apricot kernel oil (AK oil) by using an animal model of early pregnancy in adult BALB/c mice. Materials and Methods: Fifty adult BALB/c mice were first acclimated and then mated. Thirty-two confirmed pregnant mice were allocated into four groups. Monitoring involved recording weight… https://www.jrnls.org/phm/22/4/1402 https://www.jrnls.org/phm/22/4/1402 Thu, 01 Jan 2026 00:00:00 GMT Bo Xiong, Jianju Zhou, Hang Li, Yuanchao Wen Pharmacognosy Magazine Background: Tanshinone (TSL) is a good traditional Chinese medicine with a wide range of applications. Whether it plays a role in ischemic cerebral infarction is unclear. Objectives: This study aims to explore the mechanism of tanshinone (TSL) to improve endoplasmic reticulum stress injury in mice with ischemic cerebral infarction by regulating miR-29 and inhibiting the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signaling pathway. Materials and Methods: Ischemic cerebral… https://www.jrnls.org/phm/22/4/1413 https://www.jrnls.org/phm/22/4/1413 Thu, 01 Jan 2026 00:00:00 GMT Yujing Meng, Zhenyu Zhao Pharmacognosy Magazine Background: Prostate cancer is one of the most common malignancies in men, and immune escape is one of the major challenges in development and treatment. In a hypoxic environment, tumor cells may reduce or stop expressing antigens, thereby avoiding recognition by the immune system and increasing the risk of immune escape. Objectives: The purpose of this study is to explore the inhibitory effect of the calcitonin gene-related peptide (CGRP)- carrying liposome nano-delivery system on the immune… https://www.jrnls.org/phm/22/4/1424 https://www.jrnls.org/phm/22/4/1424 Thu, 01 Jan 2026 00:00:00 GMT Suhas Tambe, P. Sivakami Sundari, Geetha Kannoth Mukundan Pharmacognosy Magazine Background and Objectives: Nutraceuticals are products being used as food and medicines for the treatment of several chronic diseases. The herbal nutraceuticals are gaining importance because of a wide variety of biological actions due to the presence of phytochemicals, such as alkaloids, glycosides, terpenoids, oils, tannins, and several others, like anthocyanins. These anthocyanins are water-soluble pigments found in plants as secondary metabolites and can be of great therapeutic interest for… https://www.jrnls.org/phm/22/4/1438 https://www.jrnls.org/phm/22/4/1438 Thu, 01 Jan 2026 00:00:00 GMT Pengcheng Shen, Ying Lan, Zhe Bai Pharmacognosy Magazine Background: Sepsis-associated acute lung injury (SALI) is characterized by an uncontrolled inflammatory response and cell apoptosis, with macrophage apoptosis playing a key role in alveolar barrier disruption. Spermidine (SP), as a natural polyamine, has shown potential in anti-aging and immune regulation, but its intervention effect and mechanism on macrophage apoptosis in SALI are not yet clear. Objectives: This study aimed to investigate the interventional effect of SP on macrophage… https://www.jrnls.org/phm/22/4/1449 https://www.jrnls.org/phm/22/4/1449 Thu, 01 Jan 2026 00:00:00 GMT Xi Jiang, Yubo Yang, Hanqing Zhang, Huidan Dai, Yuyang Huang, Xuefeng Yu Pharmacognosy Magazine Background: Diabetic foot ulcer, a severe complication occurring in diabetic patients, lacks effective remedies at present. Objectives: The objective of this research is to investigate the impacts of exogenous irisin on diabetic wounds in mice and explore the associated mechanisms. Materials and Methods: An animal model was constructed by administration of streptozotocin (STZ) (50 mg/kg) in mice to simulate a diabetic condition. A full-thickness excisional wound was produced on the dorsal skin… https://www.jrnls.org/phm/22/4/1457 https://www.jrnls.org/phm/22/4/1457 Thu, 01 Jan 2026 00:00:00 GMT Zhonghua Wu, Wu Xie Pharmacognosy Magazine Background and Objectives: Quercetin, a widely distributed flavonoid in medicinal plants, exhibits potent anti-cancer effects across various malignancies. However, its pharmacological activity in gastric cancer remains insufficiently characterized. To investigate the anti-proliferative, pro-apoptotic, anti-migration, and anti-tumor effects of Quercetin against gastric cancer using in vitro (human gastric adenocarcinoma cell line [AGS], human gastric carcinoma cell line [MKN-45]) and in vivo… https://www.jrnls.org/phm/22/4/1464 https://www.jrnls.org/phm/22/4/1464 Thu, 01 Jan 2026 00:00:00 GMT Dandan Su, Qian Zheng, Qiang Wang Pharmacognosy Magazine Background: Allergic rhinitis, a worldwide health issue, is defined by immunoglobulin E (IgE)-mediated inflammation of nasal mucosa, resulting in symptoms like sneezing and nasal obstruction. The increasing incidence of allergic rhinitis globally intensifies the burden on healthcare systems, requiring thorough methods for effective management and prevention. Objectives: The current study evaluated the effects of corosolic acid against ovalbumin (OVA)-induced allergic rhinitis in mice. Materials… https://www.jrnls.org/phm/22/4/1473 https://www.jrnls.org/phm/22/4/1473 Thu, 01 Jan 2026 00:00:00 GMT Minxiang Wei, Yujie Gu, Cuiyu Han, Yuanyuan Liu, Lu Yan, Rui Gao Pharmacognosy Magazine Background: Breast cancer is the most common cancer type in women globally, constituting a substantial portion of all documented female malignancies. It is the second major cause of cancer-associated mortality in women, with over one million new diagnoses each year. Objectives: The present work evaluated the anti-cancer activity of amarogentin by assessing its growth-inhibition and apoptosis-triggering capabilities against breast cancer cells. Materials and Methods: The cytotoxic effects of… https://www.jrnls.org/phm/22/4/1481 https://www.jrnls.org/phm/22/4/1481 Thu, 01 Jan 2026 00:00:00 GMT Xi Dong, Xiaodong Li, Shuheng Li, Weiying Ge, Na Feng Pharmacognosy Magazine Background: Thyroid cancer represents the most prevalent endocrine cancer, with papillary thyroid carcinoma responsible for the most cases and presenting a significant clinical challenge due to its variable prognosis. Objectives: This work aims to examine the effects of chrysoeriol on thyroid cancer TPC-1 cells, by targeting apoptotic mediators caspase-3, caspase-8, and caspase-9 through molecular docking and evaluating their expression in TPC-1 cells treated with chrysoeriol under in vitro… https://www.jrnls.org/phm/22/4/1497 https://www.jrnls.org/phm/22/4/1497 Thu, 01 Jan 2026 00:00:00 GMT Liang Bai, Shiju Zhu Pharmacognosy Magazine Background: Cataracts, characterized by the gradual opacification of the crystalline lens, represent a primary cause of vision impairment worldwide, placing a considerable burden on individuals and healthcare systems. Understanding the precise mechanisms behind cataract formation is essential to developing targeted preventive and treatment approaches. Objectives: The current study was performed to investigate the preventive mechanisms of tomatidine against seleniteinduced cataractogenesis in a… https://www.jrnls.org/phm/22/4/1508 https://www.jrnls.org/phm/22/4/1508 Thu, 01 Jan 2026 00:00:00 GMT Hongqian Yan, Xiangyan Yu, Yinghao Su, Limei Geng, Yuzhen Pei Pharmacognosy Magazine Background: Lung cancer is a foremost global health challenge and remains the leading cause of cancer-related mortality worldwide. Despite advancements in early diagnosis and treatment, most cases are detected at advanced stages, which severely compromises survival rates. Current chemotherapeutic agents are often limited by toxicity and resistance, highlighting the urgent need for safer and more effective preventive strategies. Objectives: The present study evaluated the chemopreventive… https://www.jrnls.org/phm/22/4/1519 https://www.jrnls.org/phm/22/4/1519 Thu, 01 Jan 2026 00:00:00 GMT Zhen Wu, Mei Zhao Pharmacognosy Magazine Background: Myocardial infarction (MI) continues to be a leading contributor to illness and death worldwide, even in the face of substantial therapeutic and preventive interventions. Polygala tenuifolia, a traditional medicinal herb rich in diverse bioactive compounds, exhibits a broad range of therapeutic effects; however, its cardioprotective role has not been fully elucidated. Objectives: The herein study was proposed to examine the cardioprotective efficacy of the ethanolic extract of P.… https://www.jrnls.org/phm/22/4/1528 https://www.jrnls.org/phm/22/4/1528 Thu, 01 Jan 2026 00:00:00 GMT Ayman Saeed Alhazmi Pharmacognosy Magazine Background: Diabetes mellitus represents a significant health challenge that affects the broader population. A small tree, Commiphora gileadensis (C. gileadensis), is native to the Middle East. Objectives: This research investigated the impact of C. gileadensis on blood glucose levels, HbA1c, GLUT2, GLUT4, and lipid profile. Materials and Methods: Sixty male mice were divided into six groups: negative control, untreated diabetic, and three groups of diabetic mice treated with C. gileadensis… https://www.jrnls.org/phm/22/4/1538 https://www.jrnls.org/phm/22/4/1538 Thu, 01 Jan 2026 00:00:00 GMT Chao Shang, Junlai Song, Xiaosong Li Pharmacognosy Magazine Background: Globally, post-menopausal osteoporosis poses a major health challenge, primarily affecting elderly women because of its connection to lowered bone mineral density and increased susceptibility to fractures. This skeletal disorder not only compromises the quality of life but also contributes to a substantial socio-economic and healthcare burden. Objectives: We examined the efficacy of bavachin, a plant-derived flavonoid estrogen mimic, in mitigating osteoporosis in ovariectomized… https://www.jrnls.org/phm/22/4/1551 https://www.jrnls.org/phm/22/4/1551 Thu, 01 Jan 2026 00:00:00 GMT Jianying Sun, Qiaoyan Yin Pharmacognosy Magazine Background: Cataracts remain the foremost cause of preventable blindness globally, with oxidative stress serving as a central contributor to their pathogenesis. Given the limited accessibility of surgical intervention in many populations, there is a pressing need for effective non-surgical therapeutic alternatives. We aimed to explore the protective role of piperitone against cataract development in experimental rodents. Objectives: We aimed to explore the protective role of piperitone against…