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AJBLS · Lens · Fabrication and Characterization of Ozenoxacin and Curcumin Loaded Electrospun Nanofibre Membrane for Full Thickness Wound Healing: In vitro Assessments

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Article · Volume 13, Issue 3 · pp. 860–872

Fabrication and Characterization of Ozenoxacin and Curcumin Loaded Electrospun Nanofibre Membrane for Full Thickness Wound Healing: In vitro Assessments

A Vasanth1, P Subashini1, A Jerad Suresh2, S Mubeena3, Alan Mathew Punnoose4, Saba Maanvizhi1

  1. 1Department of Pharmaceutics, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai, Tamil Nadu, INDIA.
  2. 2Department of Pharmaceutical Chemistry, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai, Tamil Nadu, INDIA.
  3. 3Stem Cell and Regenerative Biology Laboratory, Sri Ramachandra Faculty of Clinical Research, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai, Tamil Nadu, INDIA.
  4. 4Department of Clinical Research, Sri Ramachandra Faculty of Clinical Research, Sri Ramachandra Institute of Higher Education and Research (DU), Porur, Chennai, Tamil Nadu, INDIA.

Abstract

Aim/Background: The development of advanced wound care solutions is critical due to the significant global impact of chronic and acute wounds. This study focuses on fabrication of a biodegradable and biocompatible nanofibre scaffold for enhanced wound healing, combining antimicrobial and anti-inflammatory properties.Materials and Methods: The present research work was carried out during December 2023 to July 2024. Nanofibres were developed using electrospinning with a Polyvinyl Alcohol (PVA) and gelatin blend, incorporating with ozenoxacin and curcumin as therapeutic agents.Results: The viscosity of the polymer solution prior to electrospinning was found to be at 39.48 Pa.s, ensuring optimal fibre formation. Scanning Electron Microscopy confirmed uniform fibres with diameters between 50-114 nm. Fourier-Transform Infrared Spectroscopy (FT-IR) and X-ray Diffraction (XRD) analyses verified that there is no chemical interaction and further crystalline nature of the incorporated agents respectively. In vitro release studies demonstrated a sustained release profile of both ozenoxacin and curcumin over 24 hr, indicating prolonged therapeutic potential.Conclusion: This dual-functional scaffold addresses infection control and inflammation reduction, offering a comprehensive approach to wound management and making it a promising candidate for advanced wound care applications.

Keywords: Electrospinning; Nanofibres; Ozenoxacin; Wound healing

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