Peer-Reviewed · Quarterly

International Journal of Pharmaceutical Investigation

A Journls Publication

The International Journal of Pharmaceutical Investigation aims to disseminate high-quality peer-reviewed scientific research and advance knowledge in all areas of Pharmaceutical Sciences, including pharmaceutics, nanotechnology, drug delivery, biopharmaceutics, regulatory sciences and more. International Journal of Pharmaceutical Investigation is a comprehensive resource for both professionals and researchers in the field of pharmaceutical sciences. Its broad focus spans a variety of categories within the field, including pharmaceutical drug delivery, providing the latest in research, reviews, and commentaries on current developments. The journal publishes original research articles, comprehensive review articles, case reports, short communications, letters to the editor, commentaries and editorials on topics of current interest. Manuscripts focusing on pharmaceutical innovation, novel drug delivery approaches, quality management, regulatory pathways, and other emerging areas within the pharmaceutical field are particularly encouraged. The scope of the journal covers both fundamental and applied aspects of disciplines such as pharmaceutics, nanotechnology, biopharmaceutics, pharmacokinetics, industrial pharmacy, pharmacognosy, medicinal chemistry, pharmacology, pharmaceutical regulatory affairs, intellectual property and more. Submissions with clinical, technological, regulatory or practical implications that can further pharmaceutical research and development are also within the scope. Through rigorous peer review and a rapid publication process, the journal aims to effectively disseminate significant scientific findings to researchers, academics and professionals engaged in pharmaceutical sciences and related industries on a global platform.
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Editorial board
Editors' Choice · Review

AI-Based Approaches for Early Detection and Prevention of Diabetes

Neeta Rai, Poonam R Inamdar, Jisha joseph, Omkar Kokate, Ajinkya Mote, Shivanjali Tagade, Narendra Mukesh Vishwakarma, Aryan Mangesh Vishwakarma, Pooja Malviya, Anjita Singh Thakur, Viren Mandlecha, Piyush Jangid

Diabetes mellitus is a chronic and multifaceted disorder representing a major global health concern. The two primary forms, Type 1 and Type 2 diabetes, differ in origin and progression yet share serious complications, including cardiovascular disease, kidney impairment, and nerve damage. In recent years, Artificial Intelligence (AI) has emerged as a transformative tool for early detection, treatment optimization, and prevention of diabetes-related risks. This review examines the role of AI in diabetes management, focusing on its integration into early diagnostic systems, personalized treatment planning, and risk prediction based on diverse and large datasets. These data sources include medical history, lifestyle patterns, and genetic profiles. AI-based models, particularly machine learning algorithms and neural networks, demonstrate improved accuracy in identifying diabetes and enabling timely intervention. AI-powered wearables and mobile applications support continuous self-monitoring and provide real-time recommendations for glycemic control. Moreover, the application of AI within traditional medical systems such as Ayurveda and Unani shows potential for enhancing diagnostic precision and individualized care. However, challenges persist, including inconsistent data quality, algorithmic limitations, and concerns regarding patient data privacy. Advancements in big data analytics and IoT technologies continue to expand the scope of AI in diabetes care. AI is reshaping diabetes management by improving clinical outcomes, reducing healthcare costs, and contributing to global efforts to mitigate the burden of the disease.

Read Full TextPDFDOI: 10.5530/ijpi.20260093

In This Issue

pp. 1202–1724
  1. 01
    Review Article

    AI-Based Approaches for Early Detection and Prevention of Diabetes

    Neeta Rai, Poonam R Inamdar, Jisha joseph, Omkar Kokate, Ajinkya Mote, Shivanjali Tagade, Narendra Mukesh Vishwakarma, Aryan Mangesh Vishwakarma, Pooja Malviya, Anjita Singh Thakur, Viren Mandlecha, Piyush Jangid

    IJPI 2026, 16, 4, 1202–1209

  2. 02
    Review Article

    Bridging the Digital Gap: A Comparative Analysis of Electronic Regulatory Submission Systems in India and Established Markets

    Mukesh Kumar Malik, Rekha Dhull, Raman Sureshkumar

    IJPI 2026, 16, 4, 1210–1215

  3. 03
    Review Article

    Biosensor-Based Innovations in Therapeutic Drug Monitoring: Bridging Traditional Methods and Precision Medicine

    K Pavani Reddy, Katika Nizamuddin, Haranath Chinthaginjala, E Bhargav, Kavadi Kartikeya, Kothakota Kousar, Chennavaram Kurmila, Maddileti Repollu

    IJPI 2026, 16, 4, 1216–1230

  4. 04
    Review Article

    Toward Application of Microsponges for Topical Drug Delivery: A Review

    Rajashree Shashidhar Masareddy, Archana Sidagouda Patil, Ankita Kashinath Patil, Ravikiran Ramachandra Kanabargi, Pooja Prakash Rayanade

    IJPI 2026, 16, 4, 1231–1243

  5. 05
    Review Article

    Pharmaceutical Microbiology: Navigating Future Challenges and Innovations

    Ritu Sapra, Maitry Suthar, Khushboo Arora, Aakansha Meval, Akanksha Patel, Niyati Shah

    IJPI 2026, 16, 4, 1244–1250

  6. 06
    Review Article

    Smart Implants: Transforming Drug Delivery Systems

    Sakshi Wankhede, Anil Pethe

    IJPI 2026, 16, 4, 1251–1261

  7. 07
    Review Article

    Artificial Intelligence and Machine Learning in GRDDS

    Balijepalli Murali Krishna, Chandra Sekhar Patro, Ch. Taraka Ramarao

    IJPI 2026, 16, 4, 1262–1272

  8. 08
    Review Article

    Leishmaniasis: Complexities and Burden of a Vector-Borne Neglected Tropical Disease

    Mohammed Tarique, Mohiuddin Khan Warsi, Mohd Imtiaz Nawaz, Osama Ali Almuzaini, Mahjabeen Rahmani, Mohammad Azhar Kamal

    IJPI 2026, 16, 4, 1273–1284

  9. 09
    Review Article

    Integrated Risk Assessment of Manufacturing Processes, Safety, and Nitrosamine Contaminants in the Pharmaceutical Industry: A Comprehensive Review

    Mayur Rajeshwar Dandekar, Pankaj Mandpe, Swati Satalkar, Deepak Khobragade

    IJPI 2026, 16, 4, 1285–1299

  10. 10
    Review Article

    Recent Advances in Bioactive Hydrogel Composites for Wound Healing: Mechanisms, Materials and Clinical Prospects

    M Sindhu Kumari, Fatima Sanjeri Dasankoppa, Hasanpasha N Sholapur, M Mahesh Yadav, M.A. Umarfarooq, Arunkumar Gundaiah Ramesh, Pratiksha Akki, Akshay Shamnewadi, Rakshitha N Hemadri, Vijayakumar Murugesan

    IJPI 2026, 16, 4, 1300–1311

  11. 11
    Review Article

    Digital Defence in Healthcare: Medical Device Cyber Security in the EU and USA

    Lakshmi Prasanthi Nori, Brahmaiah Bonthagarala, Cherukuri Harsha Vardhan, K.Lalitha Sri N V Sai Lakshmi, Sarapenta Sravani, Gumpati Supriya, Venkateswara Raju Kalidindi

    IJPI 2026, 16, 4, 1312–1322

  12. 12
    Review Article

    Carbazoles and Tetrahydro carbazoles as Potential Therapeutic Agents- A Review on Its Chemistry, Synthesis and Biological Evaluation

    Sree Janardhanan Vaithiyanathan, Nisha Vijayan Thankam, Mathan Swami, Ganna Anitha

    IJPI 2026, 16, 4, 1323–1337

  13. 13
    Review Article

    Integrative Approaches to Chronic Pain Management: Insights from Ayurveda and Modern Medicine

    Sakshi Wankhede, Anil Pethe

    IJPI 2026, 16, 4, 1338–1345

  14. 14
    Review Article

    From Data to Decisions: The Digital Transformation of Modern Healthcare

    Lakshmi Prasanthi Nori, Nagineni Sudarshan Rao, Kiran Manda, M.S.Raghu Bapiraju, Yarra Priyanka, Boyina Lakshmi Venkata Maneesh, Addala Bhargavi Satya, Kondabolu Raghuram, K Venkateswara Raju

    IJPI 2026, 16, 4, 1346–1357

  15. 15
    Review Article

    Biological Mechanisms Driving Chemoresistance in Oral Squamous Cell Carcinoma (OSCC): A Review

    Kaniga Pandi, Binoy Varghese Cheriyan, Nimithasree Keerthivasan, Mridula Dhanapal Saravanan, Dhanavarsha Govindaraj, Jai Anand Jagadeesan, Dinesh Kumar Eshwaravelu, Sam Helinto, Dharshini Jaisankar Hindumathi, Sowmiya Philip, Pradhosh Sakthivel, Rajeshkumar Thirupathi, Revathy Kumar

    IJPI 2026, 16, 4, 1358–1376

  16. 16
    Review Article

    Emerging Analytical Strategies for Screening Hydrochlorothiazide in Fixed Dose Combinations: A Comprehensive Review

    Sree Janardhanan Vaithiyanathan, Nandini Goudar

    IJPI 2026, 16, 4, 1377–1383

  17. 17
    Review Article

    Recent Progress in 3D Printing of Pharmaceuticals: Personalized Medicine and On-Demand Dosage Forms

    Abubakar Mohamedali Omer Idress, Amgad Gamal Abdulrahman Abbas, R. Shirisha, K. Venkata Janardhanreddy, M. Rizwana, Nawaz Mahammed

    IJPI 2026, 16, 4, 1384–1395

  18. 18
    Review Article

    Ozonated Oils for Wound Healing and Role of Emulgel on the Enhanced Topical Delivery

    Sagar Mathad, Hasanpasha N Sholapur, Fatima Sanjeri Dasankoppa, Arunkumar Gundaiah Ramesh, Kamaladevi Kshatriya, Shreya Ajay Prabhu, Vijaykumar Meti, ST Bhagawati, Vijayakumar Murugesan

    IJPI 2026, 16, 4, 1396–1409

  19. 19
    Original Article

    Influence of Gender and Educational Background on Pharmacy Students’ Perception of CAMs: A Survey-Based Study

    Ramasamy Devendran Dhanushya, Ramaiyan Velmurugan, James Jemimah Smileyn, Rangadurai Pavithra, Babu Krishnapriya, Ravichandran Praveen

    IJPI 2026, 16, 4, 1410–1416

  20. 20
    Original Article

    Everolimus-Induced Hyperglycemia and its Clinical Significance: A Retrospective Study

    Yukio Kadokawa, Akitoshi Tatsumi, Fukunori Kawahara, Saki Tanaka, Hiroki Osako, Satoshi Hasegawa, Kenji Takeda, Mari Takagi

    IJPI 2026, 16, 4, 1417–1423

  21. 21
    Original Article

    Monkeypox Transmission through Human Interaction: A Compartmental Model Study

    Naresh Kumar Jothi, Senthil Kumar Dayalan, Deepa Sunder Rajan, Lakshmi Anil Madheshiya

    IJPI 2026, 16, 4, 1424–1433

  22. 22
    Original Article

    Design, Optimization, and Evaluation of Lincomycin Hydrochloride Transdermal Patches for Sustained Drug Release and Improved Antimicrobial Efficacy

    Pratiksha Akki, M Mahesh Yadav, Fatima S Dasankoppa, Agadi Hiremath Viswanatha Swamy, M Pradeep Kumar, C. Manjula, Muneendra, Rohan Latwade, Shreya A. Prabhu, Reshma Vibhuti

    IJPI 2026, 16, 4, 1434–1444

  23. 23
    Original Article

    Development of Azilsartan Nanoparticles via Hydrolysis for Enhanced Drug Delivery

    Anbarasu Velan, Subramanian Somaskanthan

    IJPI 2026, 16, 4, 1445–1450

  24. 24
    Original Article

    Simultaneous Estimation of Moxifloxacin and Tolfenamic Acid: Development and Validation of UV-visible, HPLC, and HPTLC Methods

    Seema A. Gosavi, Pratiksha D. Bornare, Jyoti B. Tangde, Aditi S. Kulkarni

    IJPI 2026, 16, 4, 1451–1456

  25. 25
    Original Article

    Pilot Study Evidence on Cardiac Benefits of Empagliflozin, A Changing Landscapes in Heart Failure Treatment

    Robin George, Irshad Pasha, Bettur Jayappa Mahendra Kumar

    IJPI 2026, 16, 4, 1457–1463

  26. 26
    Original Article

    Statistical Optimization of Nano Emulsion-Based Gel of Efinaconazole for Onchomycosis

    Sagarla Usharani, Mohammed Mahboob Shareef, Ruhi Anjum, Vasavi Devireddy, Naseeb Basha Shaik, Palghat Krishnamani Lakshmi, Prasanthi Domaraju

    IJPI 2026, 16, 4, 1464–1473

  27. 27
  28. 28
  29. 29
    Original Article

    A Process for Eco-Sustainable Extraction of Cytotoxic Flavonoids from Muntingia calabura L. using Sonication Method Optimized by Quality by Design Approach through Central Composite Model

    Raj Deelip Mayanna, Siddhesh Santosh Bandekar, Shailendra Sanjay Suryawanshi, Mahesh Shivabasappa Palled, Priya Patil, Tanay Aniket Bhingurde, Sairaj Tukaram Bhogan, Ronak Dsouza, Yallurkar Siddhkala Suresh, Snehal Pundalik Yadav, Ashlesha Vilas Bhatakande, Soumya Ashok Biradar, Vrushali Vijay Patil, Arif Salim Jamadar

    IJPI 2026, 16, 4, 1489–1497

  30. 30
    Original Article

    Predictive Application of Hansen Solubility Parameters in the Design of Methocarbamol-Ascorbic Acid Cocrystals for Solubility and Dissolution Enhancement

    Muvvala Divya, Shaheen Begum, Mounika Yammani, Basuthkar Vanitha Bai, Dudekula Usha Rani

    IJPI 2026, 16, 4, 1498–1505

  31. 31
    Original Article

    Design and Optimization of Agmatine Sulphate Loaded Solid Lipid Nanoparticles for Neurological Disorders: A DOE Approach

    K H Harish, Agadi Hiremath Viswanatha Swamy

    IJPI 2026, 16, 4, 1506–1518

  32. 32
    Original Article

    Adverse Drug Reactions and their Determinants among Tuberculosis Patients Receiving Treatment at a Tertiary Care Centre in South India

    Niloufur Syed Bashutheen, Arivarasan Barathi, Logeswari Balaji Mani, Sowmya Anbazhagan, Rajan Rushender

    IJPI 2026, 16, 4, 1519–1526

  33. 33
  34. 34
    Original Article

    Structure-based Screening of Bacopa monnieri Compounds as Potential Anti-Breast Cancer Agents

    Maryam Musleh Althobiti

    IJPI 2026, 16, 4, 1535–1540

  35. 35
  36. 36
    Original Article

    Analytical Method for Estimation of Enalapril by UV Spectrophotometry Using Hydrotropic Solubilization: AGREE Metric Evaluation

    Nuziveeti Lakshmi Durga Bhavani, Lankadi Devi, Bolapati Gayathri Priya, Bikkina Aruna, Bommina Abhisri, G. Yuthika Lakshmi, Lakshmi Prasanthi Nori

    IJPI 2026, 16, 4, 1550–1556

  37. 37
    Original Article

    Maslinic Acid as a Candidate Small-Molecule CDK4 Inhibitor for Lung Cancer

    Rashed Mohammed Alghamdi

    IJPI 2026, 16, 4, 1557–1566

  38. 38
    Original Article

    Neurodiversity-Inclusive Leadership: A Conceptual Framework for Enhancing Innovation and Organizational Climate

    Tiyagura Nagaraja Kumari, Bachunaga Kishore Babu, Sree Pavani Vanteddu, K. Suryanarayana, Sripathi Kalvakolanu

    IJPI 2026, 16, 4, 1567–1577

  39. 39
    Original Article

    Integration of Green Chemistry Approach for Development of Box-Behnken Design Assisted RP-HPLC Method for Estimation of Nepafenac in Ophthalmic Dosage Form: A QbD Supported Degradation Approach

    Divya Ratnakumar Patil, Mahesh Palled, Shailendra Sanjay Suryawanshi, Priya Prakash Shetti, Vrushali Patil, Tanay Bhingurde, Simran Gawas, Ronak Dsouza, Sairaj Bhogan, Rakshita Hirakal, Siddhesh Bandekar, Vittal Gavali

    IJPI 2026, 16, 4, 1578–1592

  40. 40
  41. 41
    Original Article

    Multi-Target Inhibition of Breast Cancer Receptors by Pomegranate Peel Phytochemicals: An Integrated Docking, MD Simulation, and DFT Study

    Magesh Mohan, Renukadevi Jeyavelkumaran, Sanjay Valliappan, Shakthi Harikrishnan, Kadir Aravindan, Balaji Ravikuma

    IJPI 2026, 16, 4, 1601–1621

  42. 42
    Original Article

    Comparative Analysis of Three COVID-19 Vaccines in Indian Metros

    Md. Zeyaullah, Kamal Ahmad

    IJPI 2026, 16, 4, 1622–1628

  43. 43
    Original Article

    Development and Optimization of a Validated UV Spectrophotometric for Simultaneous Estimation of Thymoquinone and Temozolomide

    Krutika Lolsure, Vijay Kumbar, Priya Shetti, Mitali Kubade, Malleswara Peram

    IJPI 2026, 16, 4, 1629–1634

  44. 44
    Original Article

    Mechanistic Investigation of Hidden Flavonoids Isoorientin and Hyperin as Pancreatic Lipase Inhibitors Using Molecular Simulations and Machine Learning Correlation

    Sruthi Sai Kaveripakam, Sreedevi Adikay, Sowmya Venkata Donthamsetty, Surekha Lakshmi Khandavilli

    IJPI 2026, 16, 4, 1635–1641

  45. 45
  46. 46
    Original Article

    Thematic Structure and Evolution of a Pharmaceutical Sciences Research Corpus from Dr. Anroop Nair

    K. K Mueen Ahmed, M Chaman Sab, Mohammed Yunus, Shery Jacob, Jigar N. Shah, Hiral J. Shah, Mahesh Attimarad, Sreeharsha Nagaraja, Rashed M. Almuqbil, Bandar E. Al-Dhubiab, Katharigatta N. Venugopala, Abdullah M. Alotaibi, Ahmed S. Alnaim

    IJPI 2026, 16, 4, 1657–1665

  47. 47
  48. 48
  49. 49
    Original Article

    Computational Simulation of Monoamine Oxidase (PDB ID: 2BXR) “Molecular Docking, Molecular Dynamics, and 3D-QSAR Analysis of 10H-Phenothiazin-1-yl Derivatives Targeting Enzymes”

    Sanket Keshav Tambe, Rohit Jaysing Bhor, Sagar Dattatray Magar, Mayur Shivaji Bhosale, Shubham Popatrao Mankar, Datta Macchindra Abhale, Sachin Tukaram chavan, Gaurav Subhash Damre

    IJPI 2026, 16, 4, 1696–1718

  50. 50
    Original Article

    Assessment of Health-Related Quality of Life after the Second Cycle of Chemotherapy in Esophageal Cancer Patients: A Prospective Cross-Sectional Study

    Vishal Kulkarni, Kavya Mattikatti, Manasa Desai, Darshan Randewadi, Nida Sirdesai, Sanatkumar Bharamu Nyamagoud, AHM Viswanatha Swamy

    IJPI 2026, 16, 4, 1719–1724