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FRA · Lens · The Rat Ovaries after U-74389G Process

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Article · Volume 13, Issue 1 · pp. 29–33

The Rat Ovaries after U-74389G Process

C Τsompos1, C Panoulis2, A Triantafyllou3, C G Zografos4, E Gerakis5, S Gerakis5, A Papalois6

  1. 1Department of Gynecology, Anticancer Hospital of Thessaloniki “Theageneio”, Thessaloniki, HELLAS (GREECE).
  2. 2Department of Obstetrics and Gynecology, Aretaieion Hospital, Athens University, Athens, Attiki, HELLAS (GREECE).
  3. 3Department of Biological Chemistry, Athens University, Athens, Attiki, HELLAS (GREECE).
  4. 4Department of Surgery, Ippokrateion General Hospital, Athens University, Athens, Attiki, HELLAS (GREECE).
  5. 5Experimental Research Centre, ELPEN Pharmaceuticals, S.A. Inc., Co., Pikermi, Attiki, HELLAS (GREECE).
  6. 6Experimental, Educational and Research Center, ELPEN, European University Cyprus, School of Medicine, CYPRUS.

Abstract

Background: This study co-evaluated the 4 quoted histologic variables after U-74389G (L) administration. The calculation was based on the results of 2 preliminary studies, each one evaluating two respective histologic variables of Ovarian Epithelium Edema (OE), Oophoritis (OO), Ovarian Epithelium Karyorrhexis (OK), Ovarian Congestion (OC); in an induced ischemia reperfusion animal experiment. Furthermore, the Cytokine (TNFα) and the marker foroxidative stress Malondialdehyde (MDA) were also calculated.Materials and Methods: The 2 main experimental endpoints at which the OE, OO and OK, OC and TNFα, MDA scores were evaluated was the 60th reperfusion min (for the groups A and C) and the 120th reperfusion min (for the groups B and D). Specially, the groups A and B were processed without drugs, whereas the groups C and D after L administration.Results: The first preliminary study showed that L has a very significant recessing potency for OE and OC together (p-values=0.0157) within the “without lesions” alterations 0.1772727 [-0.3191054 - -0.03544]. The second preliminary study showed that L had a non-significant recessing potency for OK and OC within the “without lesions” grade 0.1772727 [-0.3716027 - +0.0170573] together (p-values=0.0726). These 2 studies were co-evaluated since they came from the same experimental setting. This study co-evaluated the combined diagnostic values of the four variables together. Separate calculations were performed for TNF-α and MDA scores.Conclusion: L administration significantly suppressed the 4 histologic variables within the “without lesions alterations” score 0.1772727 [-0.3208232 - -0.0337223] (p-value=0.0169), non-significantly reduced the TNF-α levels by 4.69% [+8.40%] (p-value=0.5749) and significantly reduced the MDA levels by 9.85%+2.66% (p-value=0.0005).

Keywords: Ischemia; U-74389G; Ovarian epithelium edema; Ovarian congestion; Ovarian epithelium karyorrhexis; Oophoritis; Reperfusion

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