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FRA · Lens · Comparative Hypertestosteronemic Effects of the Erythropoietin and the U-74389G

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Article · Volume 14, Issue 1 · pp. 27–31

Comparative Hypertestosteronemic Effects of the Erythropoietin and the U-74389G

Constantinos Tsompos1, Constantinos Panoulis2, Aggeliki Triantafyllou3, Constantinos Zografos4, George C. Zografos5, Apostolos Papalois6

  1. 1Department of Gynecology, General Hospital of Athens “G. Gennimatas”, Athens, HELLAS (GREECE).
  2. 2Department of Obstetrics and Gynecology, Aretaieion Hospital, Athens University, Athens, Attiki, HELLAS (GREECE).
  3. 3Department of Biological Chemistry, Athens University, Athens, Attiki, HELLAS (GREECE).
  4. 4Department of Surgery, Laikon General Hospital, Athens University, Athens, Attiki, HELLAS (GREECE).
  5. 5Department of Surgery, Ippokrateion General Hospital, Athens University, Athens, Attiki, HELLAS (GREECE).
  6. 6Experimental, Educational and Research Center, ELPEN Pharmaceuticals Co Inc SA HELLAS, Cyprus European University, School of Medicine, CYPRUS.

Abstract

Background: This study is to find out in which direction two antioxidant promising molecules, the erythropoietin and the U-74389G, affect serum Testosterone (T) levels and what the magnitude of this alteration is. The posttreatment effects on serum Testosterone (T) levels were calculated, separately by each drug and afterwards a comparative calculation was following.Objectives: The estimation was extracted by the results of the 2 previous studies, each of which had estimated a certain influence, after the respective drug administration in an induced Ischemia-Reperfusion (IR) rat experiment.Materials and Methods: The 2 temporal experimental endpoints at which the serum T levels were measured were the 60th reperfusion min (for the 3 groups A, C and E) as well the 120th reperfusion min (for the other 3 groups B, D and F). Especially, the groups A and B were the placebo ones, the groups C and D were the post Epo; whereas the groups E and F were the post L administration.Results: The first previous study of Epo presented a non-significant hypertestosteronemic effect by 0.276%±0.272% (p-value=0.3006). Similarly, the second previous study of U-74389G presented also a non-significant hypertestosteronemic effect by 0.111%±0.179% (p-value=0.5245). The results of these 2 studies co-calculated as belonging to the same experimental setting, provided the outcome of L being just by 0.4046004 [0.4035126 - 0.4056911] less hypertestoteronemic than Epo (p-value=0.0000).Conclusion: The intrinsic antioxidant capacity of U-74389G ascribes just 0.4046004 [0.4035126 - 0.4056911] less hypertestoteronemic influence than Epo (p-value=0.0000).

Keywords: Ischemia; Erythropoietin; U-74389G; Serum testosteronelevels; Reperfusion; Comparative hypertestosteronemia

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