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FRA · Lens · Membrane stability and methaemoglobin content of human erythrocytes incubated in aqueous leaf extract of Nicotiana tabacum product

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Article · Volume 2, Issue 4 · pp. 56–61

Membrane stability and methaemoglobin content of human erythrocytes incubated in aqueous leaf extract of Nicotiana tabacum product

Chikezie P.C.1, Akuwudike A. R.1, Chikezie C. M.1

  1. 1Department of Biochemistry, Imo State University, PMB 2000, Owerri, Nigeria.

Abstract

The present study seeks to ascertain membrane stability and methaemoglobin content (%MetHb) of human erythrocytes suspended in aqueous leaf extract of N. tabacum. Erythrocyte membrane stability (%EMS) and %MetHb were measured by spectrophotometric method. Erythrocytes incubated in the five experimental concentrations of N. tabacum exhibited higher tendency to haemolyze in phosphate buffered saline solution [PBS] > 0.54 g/100 mL, whereas erythrocytes incubated in aqueous extracts of [N. tabaccum] = 0.4 and 0.8 mg/100 mL showed relatively lower level of haemolysis in [PBS] Membrane stability Methaemoglobin N. tabacum Erythrocytes

Keywords: Membrane stability; Methaemoglobin; N. tabacum; Erythrocytes

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