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FRA · Lens · Radical scavenging ability of glycyrrhizin

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Communication · Volume 3, Issue 1 · pp. 40–42

Radical scavenging ability of glycyrrhizin

Kimie Imai1, Yushi Takagi1, Ayano Iwazaki1, Kunio Nakanishi1

  1. 1Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573 0101, Japan.

Abstract

Glycyrrhizin (Gly), a major constituent of licorice root, has been used for the treatment of chronic liver diseases in Japan. Reports have been contradictory as to whether Gly scavenges hydroxyl radicals and superoxide anion radicals. We examined the radical scavenging abilities of Gly and glycyrrhezic acid (GA), an aglycon of Gly. Gly and GA did not scavenge hydroxyl radicals or superoxide anion radicals, but both scavenged 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, in contrast to previous reports. The scavenging abilities of Gly and GA might play a role in the treatment of chronic liver diseases.

Keywords: Glycyrrhizin (Gly); Superoxide anion radical; 1; 1-Diphenyl-2-picrylhydrazyl (DPPH); Hydroxyl radical; Glycyrrhezic acid (GA)

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