Article · Volume 9, Issue 2 · pp. 66–72
Antioxidant, Anti-inflammatory, Antiproliferative and Antimicrobial Activities of Combretum glutinosum and Gardenia aqualla Extracts in vitro
Bawa Yusuf Muhammad1,2, Nadia Zaky Shaban1, Fatima Hassan Elrashidy1, Doaa Ahmed Ghareeb1,3
- 1Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, EGYPT..
- 2Department of Biochemistry and Molecular Biology, Faculty of Science, Nasarawa State University Keffi, NIGERIA..
- 3Bioanalytical centres of Excellence: Phar maceutical and fermentation Department, GEBRI, SRAT-city, Alexandria, EGYPT..
Abstract
Objectives: Plants represent a diverse template that could be tapped as sources of novel drugs. This study highlights antioxidant, anti-inflammatory, anti-proliferative and as well antimicrobial activities ofCombretum glutinosum (BE) and Gardenia aqualla (GE) roots ethanol extracts.Methods: The Biological activities were evaluated using the established standard methods.Results: Both extracts exhibited antioxidant and anti-inflammatory activities with BE being better than GE. Anti-proliferative (cytotoxicity) assay on HepG2 and BHK-21 cell lines similarly revealed that BE (IC50: 55, SI: 1.81) is more cytotoxic and more selective than GE (IC50: 478.60, SI: 0.99). For the antimicrobial study, BE inhibited the growth of pathogenic bacteria; Pseudomonas aeruginosa, Staphylococcus aureus, Vibrio species and E. coli, while GE extract showed activity against Candida albicans.Conclusion: We conclude that Combretum glutinosum extract (BE) possessed the most robust activity from this study. Hence, it could be a promising source of novel drug with wide biological activities, especially antioxidant and anticancer activities.
Keywords: Antioxidant; Cytotoxicity; Cancer cell line; Anti-microbial; Drug discovery
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