Article · Volume 13, Issue 3 · pp. 271–273
Isoniazid Induced Generalized Lichenoid Drug Eruption: An Unusual Offender
Pratima Singh1, Deepak Nathiya1, Sonal Jain2, Preeti Raj1, Supriya Suman1, Balvir Singh Tomar3
- 1Department of Pharmacy Practice, Institute of Pharmacy, NIMS University, Jaipur, Rajasthan, INDIA.
- 2Department of Dermatology, Venereology and Leprosy, NIMS University, Jaipur, Rajasthan, INDIA.
- 3Department of Gastroenterology and Hepatology, NIMS University, Jaipur, Rajasthan, INDIA.
Abstract
Introduction: Isoniazid also known as isonicotinic acid hydrazide is first line drug in anti-tubercular regimen. We report the case of lichenoid drug eruption due to this drug. Case-Report: A Sixty four-year old man received treatment for transverse myelitis with pulmonary TB. After almost four months of initiation of regimen he developed viloaceous lesions first from back and gradually involving B/L extremities. A skin punch biopsy is indicative of drug-induced lichenoid drug eruption. Isoniazid dechallenge and rechallenge confirmed the diagnosis of “Isoniazid induced lichenoid Drug eruption”.Discussion:Incidence of isoniazid induced CADR is 0.98%. Diagnosis decisionmaking should be on the basis of critical analysis of case. Role of Pharmacovigilance is crucial to understand quality and frequency of adverse drug reactions.
Keywords: Lichenoid drug eruption; Isoniazid; Tuberculosis; Cutaneous adverse drug eruption; ATT
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