Nitrofurantoin Induced Reversible Interstitial Lung Disease

ABSTRACT

Drug-induced interstitial lung disease is an increasingly common cause of morbidity and mortality. Nitrofurantoin is a broad-spectrum antibiotic used for acute uncomplicated or simple cystitis as well as for prophylaxis of recurrent infection. We recently encountered a case of Nitrofurantoin-induced interstitial lung disease in an elderly patient who was on Nitrofurantoin for a year and a half for recurrent urinary tract infections. On further evaluation, she was diagnosed with drug-induced interstitial lung disease, which was confirmed by radiographic evidence. Nitrofurantoin was discontinued and managed with low-dose systemic glucocorticoids. This case report highlights the need for close vigilance of pulmonary toxicities in patients taking long-term Nitrofurantoin therapy.

KEYWORDS

• Pulmonary toxicity
• Corticosteroids
• Nitrofurantoin
• Interstitial Lung disease
• Urinary tract infection

Showing references and in-text citations exactly as published.

• DOI10.5530/ijopp.16.4.63Copy

RELATED ARTICLES

Matched on section and article type within this issue of IJOPP.

• Article · VOLUME 16, ISSUE 4A Case Report on Contrast Media Induced Acute Kidney Injury after Percutaneous Coronary InterventionS.P. Santhosh Kumar, V. Shangavi, M.S. Reema, Sanjana Mariam Saju, Sinta Varghese, Sneha Anna Kunjumon, Swetha D · pp. 366–368Case ReportSame type: Article
• Article · VOLUME 16, ISSUE 4Psychiatric Morbidity and its Correlations in Diabetic Patients in a Tertiary Care HospitalKurupatha Menatha Jayasree, Sirisha Stephen, Kottedi Haritha, Pathan Humerakhan, Ganesh Kumar · pp. 303–313Same type: Article
• Article · VOLUME 16, ISSUE 4Evaluation of Drug Utilization in Patients with Coronary Artery Disease: Prevalence, Predisposing Factors and Prescribing Patterns in Tertiary Care Hospital in PunjabRiya Sharma, Aman Thakur, Amit Sharma, Mandeep Kaur, Yousef Saeed Alqarni, Fahad T. Alsulami · pp. 314–321Same type: Article
• Article · VOLUME 16, ISSUE 4A Study on Drug Utilization Evaluation and Health-Related Quality of Life in Hemodialysis PatientsSaba Farooqui, Puja Kundu, Sandra Simon, Savitha Amin, Sajan Francis P, Scandashree Krishnegowda · pp. 322–327Same type: Article