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IJPI · Lens · In vitro Kinetic Release Study, in vivo Hydration and Moisturizing Effect of Peel-off Oil-in-Water (O/W) Nanoemulsion Containing Kojic Monooleate for Topical Application

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Article · Volume 12, Issue 1 · pp. 75–81

In vitro Kinetic Release Study, in vivo Hydration and Moisturizing Effect of Peel-off Oil-in-Water (O/W) Nanoemulsion Containing Kojic Monooleate for Topical Application

Nur Farzana Jaslina1,2, Nur Hana Faujan1,2,3, Rosfarizan Mohamad4,5, Siti Efliza Ashari1,2,3

  1. 1Integrated Chemical BioPhysics Research, Faculty of Science, Universiti Putra Malaysia, UPM, Serdang, Selangor, MALAYSIA.
  2. 2Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, UPM, Serdang, Selangor, MALAYSIA.
  3. 3Centre of Foundation Studies for Agricultural Sciences, Universiti Putra Malaysia, UPM, Serdang, Selangor, MALAYSIA.
  4. 4Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, UPM, Serdang, Selangor, MALAYSIA..
  5. 5Bioprocessing and Biomanufacturing Research Complex, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, UPM, Serdang, Selangor, MALAYSIA.

Abstract

Background: Kojic monooleate (KMO) contains tyrosinase inhibitor and exhibits strong antioxidant activity makes it a good candidate to be incorporated into a formulation for topical application. A peel-off was chosen to ensure a better hydration effect and permeability of KMO into the skin. The objectives of this research were to analyze the kinetic release study of peel-off oil-in-water O/W nanoemulsion containing KMO and evaluate the moisturizing and hydration effect towards human volunteers.Methods: The peel-off formulation was developed by adding 27.61% w/w polyvinyl alcohol (PVA) and 1.05% w/w propylene glycol (PG). The study was performed by using Franz cell, tewameter and corneometer to analyze the release rate of KMO from peel-off O/W nanoemulsion, moisturizing, and hydration effect of formulation towards humans after 180 min of application, respectively.Results: The final formulation has a pH of 4.74, conductivity of 7.47 ± 4.05 x 10-3 𝜇S/cm, viscosity 0.1058 Pa·s and spreadability of 61.86 ± 1.71 g·cm/s. It also disports 79.99 ± 2.53 % released of KMO after 180 min of study time. The results of the hydration effect of the formulation towards human volunteers’ skin suggested that the peel-off O/W nanoemulsion containing KMO does increase the hydration of the skin by 12.33% due to the occlusive effect of KMO.Conclusion: In summary, this study presents new findings in the kinetic release study, hydration and moisturizing effect of peel-off O/W nanoemulsion containing KMO for topical application.

Keywords: Cosmeceutical application; Thin film system; Franz cell; Transepidermal water loss; Hydration

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