Review · Volume 12, Issue 3 · pp. 250–254
Threatened Ayurvedic Herb (Seeta Ashoka) Substitution Options for Menorrhagia-based on Bioactive Principle’s Molecular Docking Study
Utkarsh Ghate1, Hema Kulkarni2, Manasi Deshpande3, Mandar Akkalkotkar4
- 1Gram Mooligai (Village herbs) Co. ltd. (GMCL), Durg, Chhattisgarh, INDIA.
- 2Govt. S. D. S. college, Jamgao-R, Durg, Chhattisgarh,, INDIA.
- 3Bharati Vidyapeeth Ayurveda College, Pune, Maharashtra, INDIA.
- 4Tilak Ayurveda College, Pune, Maharashtra, INDIA.
Abstract
Molecular docking studies are used to identify cultivated/ abundant herbs such as Coriander, Burmuda grass or Asparagus as potential replacement for Seeta Ashoka- Saraca asoca (Roxb.) De Wilde, syn. S. indica Linn. a rare Indian medicinal forest plant, threatened with extinction due to over harvest. Its bark is used to make the famous Ayurvedic medicine “Ashokarishta” to treat menorrhagia and as a uterine tonic like ergot but is mostly adulterated. We tested using molecular docking studies Quercetin and other polyphenols from Coriander as potent anti-inflammatory ingredients, similar to NSAID (Non-steroidal anti-inflammatory drugs)., Polyalthia longifolia, the common adulterant is also be noted to be effective as its bark contains 30-50% of tannin than Saraca asoca, so may help in thrombosis.
Keywords: Herb; Ayurveda; Menorrhagia; Polyphenol; In silico
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