Comparative Evaluation of Dengue Virus (DENV) Serotypes Infections in Human (Homo sapiens)

Abstract

Background: Dengue virus is transmitted by the mosquito species Aedes aegypti and causes dengue fever. The single positive-stranded RNA virus of the family Flaviviridae belongs to the genus Flavivirus. There is four dengue virus (DENV) serotypes. (DENV-1, DENV-2, DENV-3, and DENV-4). Each has altered interactions with the antibodies in the human blood serum.Materials and Methods: In the study, we reported that the comparative study of dengue serotypes along with multiple sequence alignment, domain organization, structure modeling, secondary structure prediction, epitope peptide identification, including the phosphorylation sites.Results: A significant objective for future research will be to completely comprehend the auxiliary and proper angles and clarify the various jobs.Conclusion: We present a comparison of Dengue virus serotypes in this study (DENV1, DENV2, DENV3, and DENV4). We looked into dengue serotype differences in this study.

Keywords: Sequence; Amino acid; Dengue virus; Structure; Epitope; Peptides; Phosphorylation