Anti-manic and Antipsychotic Effects of Withania somnifera Extract in Rodent Model of Bipolar Disorder

Abstract

Aim: The present study was to investigate the effects of WSE improve cognitive, behavioral and mood disorders in animal models of bipolar disorder. Materials:Animals were divided into six groups each group contain 6 wistar rats of either sex ,Behavioral and memory test were carried out followed by estimation of oxidative stress and neurotransmitters in rat brain using continuous sub anesthetic dose of Amph (1.5 mg/kg, i.p) with Withania somnifera extract (300 mg/kg, i.p) and Lithium chloride (100mg/kg, i.p.) administered daily for 21 days.Results: % Alternation was decreased in rat treated with WSE as compared to control indicating that it also improved spatial memory and learning. various oxidative parameters were estimated, oxidative stress was observed the levels of SOD and GSH reduced and increased in TBARS level compared to control groups, but reduced ion in oxidative stress upon administration of Withania somnifera extract and Lithium chloride indicates ameliorating effects of Withania somnifera extract in oxidative stress.Conclusion: We concluded that WSE showed improvement in learning and memory as animals treated with WSE spent more time in open arms as compared to Amphetamine with Withania somnifera and Lithium chloride- treated rats. Overall, the findings of this work show that neurotransmitters get imbalance and change the mood and chemistry of the brain. Hence Withania somnifera extract improve neurotransmitter imbalance which is directly linked with mood, behavior, anxiety and manic episodes in an animal model of bipolar disorder.

Keywords: Withania somnifera extract; Cognitive; Behavioral; Mood disorder; Neurotransmitters; Bipolar disorder