Article · Volume 14, Issue 1 · pp. 68–75
A Box Behnken Design Optimized Nano Vesicular Transdermal Patch for Allergies
Charan Sailaja1, Pradeep Kumar Bhupalam2
- 1Department of Pharmaceutical Sciences, JNTUA, Ananthapuramu, Andhra Pradesh, INDIA.
- 2Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Affiliated to JNTUA, K. R. Palli Cross, Ananthapuramu, Andhra Pradesh, INDIA.
Abstract
Background: The work aimed to fabricate Loratadine (LRD) niosomes by employing a Box Behnken Design (BBD) and they were subsequently applied to transdermal patches utilizing BBD's solvent casting process.Materials and Methods: The prepared niosomes were assessed for their size, shape, zeta potential, and level of entrapment efficiency. The niosomal formulations that have been optimized were inserted into a patch system. Then, physico-chemical characteristics, and in vitro permeation studies were used to characterize each patch.Results: In comparison patches loaded with niosomal vesicles showed better drug release compared to the control patches. Niosomal patches had higher permeation than control patches, it was discovered. The surfactant in niosomes acts as a penetration enhancer, which helps to improve LRD permeation from niosomes.Conclusion: The work summarizes that the transdermal patches based on niosomes could efficiently deliver LRD medicines trans-dermally while preventing GIT side effects.
Keywords: Design; Kinetics; Loratadine; Niosomes; Patch; Permeation; Release
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