Amoxicillin Clavulanic Acid-induced Skin Rashes: A Case Report

Abstract

Amoxicillin-clavulanic acid is a commonly prescribed β-lactam antibiotic combination known for its broad-spectrum antibacterial activity, but it can occasionally cause hypersensitivity reactions such as skin rashes. This case describes a 40-year-old female diagnosed with Abnormal Uterine Bleeding-Adenomyosis who developed erythematous skin rashes 2 days after starting amoxicillin-clavulanic acid as part of her postoperative treatment following a total abdominal hysterectomy. The antibiotic was immediately discontinued, and the patient was treated with Inj. Chlorpheniramine maleate, 4 mg stat, leading to complete resolution of symptoms. The adverse event was assessed using the Naranjo Adverse Drug Reaction Probability Scale, yielding a score of 7, indicating a probable reaction. This case highlights the need for close monitoring of antibiotic therapy, early identification of adverse reactions, and prompt discontinuation of the causative drug to ensure patient safety and prevent recurrence.

Keywords: Abnormal Uterine Bleeding; Adenomyosis; Adverse Drug Reaction; Amoxicillin-clavulanic acid; Antibiotic Allergy; β-lactam antibiotics; Drug-Induced Hypersensitivity; Naranjo scale; Pharmacovigilance; Skin Rashes