Article · Volume 1, Issue 6 · pp. 342–347

Chemical constituents and bioactivities of Malabaila suaveolens

I. Nassar Mahmoud¹, A. Aboutabl El-Sayed², A. Maklad Yousreya³, A. El-Khrisy Ezzel-Din¹, F. Osman Abeer¹

¹aChemistry of Natural Compounds Department, National Research Centre, 12622 Dokki, Cairo, Egypt.
²bPharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr-el-Aini Street, 11562 Cairo, Egypt.
³cPharmaceutical and Medicinal Chemistry Department, National Research Centre, 12622 Dokki, Cairo, Egypt.

Abstract

Volatile oil components, fatty acids, β-amyrin, and sterols were identified in the n-hexane extract of Malabaila suaveolens Coss. fruits. Angelicin, 4,7,9-trimethyl psoralen, isopimpinellin and umbelliferone were isolated from the dichloromethane extract of the plant. 5-Hydroxy 7, 3`, 4`-trimethoxyflavone, apigenin and its 7-O-β-D-glucopyranoside were isolated from the ethyl acetate extract. From the methanol extract, a new flavonoid, apigenin 7-O-(6``-O-p-hydroxybenzoyl)-β-D-glucopyranoside (1), along with vicenin 2, acacetin 7-O-rutinoside, and 6-hydroxyapigenin 7-O-β-D-glucopyranoside were isolated. Toxicity study of n-hexane, dichloromethane, ethyl acetate extract and methanolic extracts of the plant proved that it is relatively nontoxic. The tested extracts showed significant analgesic and anti-inflammatory effects as compared with control groups and reference drugs. Also, the tested extracts showed significant antioxidant activity as compared with reference.

Keywords: Malabaila suaveolens; coumarins; flavonoids; bioactivity

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