Antihyperglycemic and antioxidant activities of active fraction from the aqueous extract of Momordica cymbalaria fruits in Streptozotocin induced diabetic rats
1, 1, 1, 1, 1, 1★★ Corresponding author
- 1Department of Biochemistry, S.V.University, Tirupati-517502, AndhraPradesh, India.
Received: 29-08-2009; Revised: 08-09-2009; Accepted: 17-09-2009.
Volume 1, Issue 6 · pp. 352–358 · 2009 · DOI:
ABSTRACT
The methanolic supernatant fraction (MSF) of the aqueous extract of Momordica cymbalaria fruits when given to streptozotocin (STZ) induced diabetic rats showed a significant reduction (65.9%, P<0.001) in fasting blood glucose levels at a dose of 0.5g/ kg.b.w. These results were compared to that of glibenclamide, an oral hypoglycemic agent. The active MSF exhibited a dose dependent scavenging activity against 2, 2-diphenly-1-picrylhydrazyl (DPPH) radicals and nitric oxide radicals with an IC50 value of 42.5 and 157.2μg/ml, respectively. Further, the MSF had relatively lower reducing power, compared to that of ascorbic acid. The total phenolic content of the fraction was found to be 132mg/gm of dry fraction. In conclusion, MSF possess antihyperglycemic and antioxidant properties, which could be due to the presence of steroidal glycosides or phenolic compounds.
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Rajasekhar, M., Babu, K. R., Vinay, K., Sampath, M., Sameena, S., & Apparao, C. (2009). Antihyperglycemic and antioxidant activities of active fraction from the aqueous extract of Momordica cymbalaria fruits in Streptozotocin induced diabetic rats. Pharmacognosy Research, 1(6), 352–358.