Article · Volume 11, Issue 4 · pp. 396–399
Two Lycopodium Alkaloids from the Aerial Parts of Huperzia phlegmaria
Dang Kim Thu1, Dao Thi Vui2, Bui Thanh Tung1
- 1Department of Pharmacology and Clinical Pharmacy, VNU School of Medicine and Pharmacy, Vietnam National University, Hanoi, VIETNAM.
- 2Department of Pharmacology, Hanoi University of Pharmacy, Hanoi, VIETNAM.
Abstract
Background: Huperzia phlegmaria has been used to enhancing memory and alleviate brain disorders. It contains high amount of alkaloids, which are potent acetylcholinesterase (AChE) inhibitor.Materials and Methods:Lycopodium alkaloids from aerial parts of H. phlegmaria were isolated by chromatographic methods. Their structures were elucidated by spectroscopic methods, including mass spectrometry and nuclear magnetic resonance. AChE inhibitory effect of isolated compounds in vitro was evaluated using Ellman’s assay.Results: These compounds were identified as fawcettidine and 12‑epilycodoline N‑oxide. Two compounds showed moderately AChE inhibitory effects with IC50 values of 33.11 µg/mL and 64.56 µg/mL, respectively.Conclusion: These isolated compounds could be promising drugs for the treatment of Alzheimer’s disease.
Keywords: 12‑epilycodoline N‑oxide; Acetylcholinesterase; Fawcettidine; Huperzia phlegmaria; Lycopodium alkaloids
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