Article · Volume 12, Issue 4 · pp. 375–379

Phytochemical and Pharmacological Screening of Begonia grandis Dryand

Srinivasarao Pendy¹, Krishna Nallamothu¹, Ganapaty Seru², Sunitha Katta², Sumanta Mondal²

¹Research and Development Wing, Divis Laboratories Ltd, Visakhapatnam, Andhra Pradesh, INDIA.
²GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, INDIA.

Abstract

Begonia grandis Dryand (Family: Begoniaceae) was screened for its phytoconstituents and evaluated for its ethnomedicinal potential as an antioxidant and hepatoprotective agent. The preliminary phytochemical studies of the B. grandis revealed the presence of alkaloids, flavonoids, glycosides, triterpenoids, and steroids. Antioxidant effect of the methanolic extract was assessed by DPPH, superoxide, hydroxyl radical scavenging activity, and hepatoprotective effect by CCl4-induced hepatotoxicity. The extract showed significant antioxidant and hepatoprotective effects at a dose of 400 mg/kg similar to that observed in ascorbic acid and silymarin.

Keywords: Antioxidant; Begonia grandis; Begoniaceae; Ethnomedicinal; Hepatoprotective; Silymarin

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