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PR · Lens · Natural Gastroprotective Remedy from the Branches of Spondias tuberosa Arruda

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Article · Volume 12, Issue 4 · pp. 455–459

Natural Gastroprotective Remedy from the Branches of Spondias tuberosa Arruda

Amanda Dias de Araujo1, George Souza Feitoza2, Fernanda Granja da Silva Oliveira3, Bruno Oliveira de Veras4, Francinete Francis Lacerda5, Nicácio Henrique da Silva2, Wolfgang Harand1, Silvania T Paz6, Mário Ribeiro de Melo-Júnior6, Jackson Roberto Guedes da Silva Almeida3, Marcia Vanusa da Silva1, Maria Tereza dos Santos Correia2

  1. 1Departments of Biochemistry, Federal University of Pernambuco; National Institute of Semiarid/Ministry of Science, Technology and Innovation (INSA/MCTI), Paraiba, BRAZIL.
  2. 2Departments of Biochemistry, Federal University of Pernambuco, Paraiba, BRAZIL.
  3. 3Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, Pernambuco, BRAZIL.
  4. 4Department of Biochemistry, Federal University of Pernambuco, Paraiba; Post-Graduation in Tropical Medicine, Federal University of Pernambuco, BRAZIL.
  5. 5Agronomic Institute of Pernambuco – IPA, BRAZIL.
  6. 6Department of Pathology, Federal University of Pernambuco, BRAZIL.

Abstract

Background: Gastric ulcers are a worldwide health problem and their poor healing is one of the most important causes for their recurrence. Several species of Spondias are used in traditional medicine for the treatment of gastrointestinal diseases, infections, and inflammation, among other conditions.Objectives: The aim of this study was to investigate the antioxidant propertiesin vitro and gastroprotective effect in mice of the methanolic extract of branches of Spondias tuberosa (MEB). MEB was screened for antioxidant activities using different methods.Materials and Methods: Measurements of total phenolic compounds, flavonoids, and tannins were also evaluated. The profile of phenolic compounds of extract was performed by high-performance liquid chromatography (HPLC). MEB was investigated for acute and chronic toxicity and gastroprotective effects against ethanol-induced lesions in Swiss mice.Results: The extract showed antioxidant activity in vitro and high content of phenolic compounds, flavonoids, and tannins. The HPLC results identified the presence of gallic acid, chlorogenic acid, caffeic acid, and t-ferulic acid. The MEB showed no acute and chronic toxicity and in doses of 50, 100 and 200 mg/kg, v. o., reduced the area of ulcerative lesions induced by ethanol in 73.74, 72.02, and 72.40', respectively.Conclusion: The oral treatment with the extract of S. tuberosabranches (MEB) showed gastroprotective and antioxidant activities.

Keywords: Antioxidants; Gastroprotective; Medicinal plants; Spondias tuberosa; Umbu

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