Preventive Medicinal Plants and their Phytoconstituents against SARS-CoV-2/COVID-19

Abstract

Pandemic coronavirus disease-2019 (COVID-19) is an infectious disease caused by the newly discovered virus “Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2)”. Considering the present scenario of COVID-19 outbreak and its impact on humankind, holistic remedies with respect to herbal medicine validated from ethnopharmacological rationale are now targeting approaches globally as a preventive care against SARS-CoV-2.Aim: This review is primarily focused on to deliver a concise fact of the coronaviridae family, pathophysiology, mechanism of action, ethnopharmacological validated Indian herbs for inhibiting the virus with possible targets. Experimental procedure:In this study, science mapping tool Bibliometrix R-package was used to perform bibliometric analysis and building data matrices for keywords co-occurrence investigation, country-wise scientific production; collaboration between the countries worldwide, co-word analysis on topic “keywords associated with SARS-CoV-2 and medicinal plants”. Results and Conclusion: Our findings is to deliver a concise knowledge about the coronaviridae family, pathophysiology, possible targets for managing the SARS-CoV-2, in addition to potential medicinal plants and their phytoconstituents against COVID-19. Target-specific inflammatory pathways due to post infection of SARS e.g. NLRP3, p38-MAPK, Metallopeptidase Domain 17; endocytosis pathways e.g. Clathrin, HMGB1 pathways are primarily highlighted along with relevant interleukins and cytokines, which directly/indirectly triggering to immune system and play a significant role. Based on selective pathways and potential lead, the outcome of our elaborated study put forward selected Indian medicinal plants that hold a very high probability as preventive care in this global crisis.

Keywords: Biblioshiny; Coronavirus; COVID-19; Medicinal plants; Phytoconstituents; SARS-CoV-2