jrnls.org logo
Submit

BROWSE ALL JOURNALS

Type 2 letters to search all 19 journals

SEE ALL 19 JOURNALS
Pharmacognosy ResearchNOW IN
Back

PR · Lens · In-silico Molecular Docking Studies of some Isolated Phytochemicals from Biophytum veldkampii against Cyclooxygenase-II Enzyme and in vivo Anti-inflammatory Activity

PDF

Article · Volume 13, Issue 4 · pp. 192–198

In-silico Molecular Docking Studies of some Isolated Phytochemicals from Biophytum veldkampii against Cyclooxygenase-II Enzyme and in vivo Anti-inflammatory Activity

Nagaraju Bandaru1, D.S.N.B.K. Prasanth1, A.Rajasekhar Reddy2, G.S.N Koteswara Rao3, Kumar V.S Nemmani4, Alla Narayana Rao1

  1. 1Department of Pharmacology, College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddesweram, Andhra Pradesh, INDIA.
  2. 2Department of Pharmaceutical Chemistry, College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddesweram, Andhra Pradesh, INDIA.
  3. 3Department of Pharmaceutics, College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddesweram, Andhra Pradesh, INDIA.
  4. 4Department of Pharmacology, Shri Vishnu College of Pharmacy, Bhimavaram, Andhra Pradesh, INDIA.

Abstract

Background: The current study estimate the anti-inflammatory activity of whole plant of Biophytum veldkampiion carageenan induced inflammation on rats compiled by molecular docking studies of phytocompounds from the plants with Cyclooxygenase II (PDB ID: 3LN1).Methods: In this research Biophytum veldkampii was subjected to extraction using methanol. In-vivo anti-inflammatory activity was assessed by using carageenan induced inflammation on rats and in-silico molecular docking studies was performed by using of Autodock 4.0.Results: The outcomes revealed that the methanolic extract has most prominenant anti-inflammatory activity at various doses. Among all the substances 2,6,3’,4’-Tetrahydroxy-2-benzylcoumaranone revealed the most effective docking rating of -6.8, which is near to Diclofenac, i.e. - 6.9, ensuring that 2,6,3’,4’-Tetrahydroxy-2-benzylcoumaranone has a strong binding fondness in between protein and ligand.Conclusion: From the results, a conclusion can be drawn that the anti-inflammatory activity of Biophytum veldkampii in both in vivoandin silico methods. This information sustains 2,6,3’,4’-Tetrahydroxy-2-benzylcoumaranone to be a useful anti-inflammatory compound beneficial to future clinical studies.

Keywords: Carageenan; Cyclooxygenase II; In-silico; Inflammation; Phytochemical

The full text of this article is available as a PDF. Open the PDF.