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PR · Lens · Attenuation of Oxidative Stress and Nephrotoxicity with Supplementation of Pimpinella tirupatiensis Tuberous Root in Streptozotocin-induced Diabetic Rats

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Article · Volume 15, Issue 4 · pp. 813–818

Attenuation of Oxidative Stress and Nephrotoxicity with Supplementation of Pimpinella tirupatiensis Tuberous Root in Streptozotocin-induced Diabetic Rats

Thopireddy Lavanya1, Kakarla Chandra Mohan2, Kesireddy Sathyavelu Reddy3, Saddala Rajeswara Reddy4

  1. 1Department of Zoology, KVR Government College for Women (A), Cluster University, Kurnool, Andhra Pradesh, INDIA.
  2. 2Department of Zoology, SCNR Government Degree College, Proddatur, Andhra Pradesh, INDIA.
  3. 3Department of Zoology, S.V. University, Tirupati, Andhra Pradesh, INDIA.
  4. 4Department of Biotechnology, Division of Ethnopharmacology, School of Herbal Studies and Naturo Sciences, Dravidian University, Kuppam, Andhra Pradesh, INDIA.

Abstract

Background: The endemic plant of Seshachalam hills, Eastern Ghats, India, known asPimpinella tirupatiensis (Pt).Objectives: It was examined in this study for its protective effects against oxidative damage in the kidney of Streptozotocin (STZ)-induced diabetic rats.Materials and Methods: After the induction of diabetes with Streptozotocin (40 mg kg-1 b.w), PTAq, an aqueous extract of Pt was directed orally at a dose of 750 mg kg-1 b.w. day-1.Results: Diabetic rats displayed significant decreases in Glutathione (GSH), ascorbic acid, and Vitamin E content (p<0.01) and significant elevations in lipid peroxidation (as MDA), uric acid content, and Xanthine Oxidase (XOD) activity (p<0.01). However, PTAq supplementation in the diabetic group resulted in significant (p<0.01) increases in Glutathione (GSH), Ascorbic Acid (AA), and Vitamin E content and declined MDA content, uric acid content, and XOD activity.Conclusion: The results advocate that Pt has the potential to avert diabetic complications triggered by oxidative stress in experimental diabetic rats and could have therapeutic implications for diabetes management in the future.

Keywords: Ascorbic acid; Glutathione; Lipid peroxidation; Non-enzymatic antioxidants; Pimpinella tirupatiensis

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