Article · Volume 16, Issue 1 · pp. 110–117
Anti-arthritic and Anti-inflammatory Activity of Ayurvedic Polyherbal Formulation in Laboratory Animals
Chandrasekar Sandanapalli Basavarajaiah1,2, Anil Tukaram Pawar1,3, Harisha Ramappa4, Vani Setty2,5
- 1Department of Pharmacology, Acharya & BM Reddy College of Pharmacy, Soladevanalli, Bangalore, Karnataka, INDIA.
- 2Department of Drugs Control, Drugs Testing Laboratory, Government of Karnataka, Palace Road, Bangalore, Karnataka, INDIA.
- 3Department of Pharmaceutical Sciences, School of Health Sciences and Technology, Dr. Vishwanath Karad MIT World Peace University, Pune, Maharashtra, INDIA.
- 4Department of Pharmacology, Government College of Pharmacy, Subbaiah Circle, Bangalore, Karnataka, INDIA.
- 5School of Pharmacy, Sri Balaji Vidyapeeth, SBV Campus, Pillaiyarkuppam, Pondicherry, INDIA.
Abstract
Background: RD/M.ph.AA-01 is an Ayurvedic polyherbal formulation, developed foramavata, which is associated with chronic inflammatory autoimmune diseases.Objectives: The study was planned to evaluate the anti-arthritic and anti-inflammatory activity of RD/M.ph.AA-01 in laboratory animals.Materials and Methods: Anti-arthritic activity of RD/M.ph.AA-01 was evaluated at 270 and 405 mg/kg doses against Complete Freund’s Adjuvant (CFA)-induced arthritis. Anti-inflammatory activity was studied using cotton pellet granuloma and formalin-induced edema in rat models. The effect of topical application of RD/M.ph.AA-01 on Croton oil ear edema in mice was also investigated.Results: Arthritis induction caused a significant (p<0.05) alteration in paw size, hematology, serum parameters, edematous tissue parameters, lipid peroxidation in the liver and histopathology of joints. These alterations were significantly (p<0.05) prevented by treatment with RD/M.ph.AA-01. In the cotton pellet granuloma, RD/M. ph.AA-01 supplementation caused significant (p<0.05) improvement in the weight of granuloma tissue, serum parameters, lipid peroxidation in the liver and histopathological changes in granuloma tissue. A significant (p<0.05) improvement in paw size, serum parameters and liver lipid peroxidation were observed by RD/M.ph.AA-01 treatment in the formalin-induced edema model. The RD/M.ph.AA-01 also significantly (p<0.05) suppressed Croton oil-induced ear edema.Conclusion:These findings showed that RD/M.ph.AA-01 possesses potent anti-arthritic and anti-inflammatory activity.
Keywords: Anti-arthritic; Anti-inflammatory; Ayurvedic polyherbal formulation
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