Evaluation of Mixer of Essential Oils and their Standard Components against Fungi Causing Superficial Mycosis in Human

Abstract

Background: Dermatophytoses are responsible for almost one-quarter of all fungal infections globally. When treatable, these challenging fungal infections of the skin, hair, and nails are becoming more resistant to standard antifungal medications and frequently call for lengthy therapeutic regimens.Objectives: Essential oils have been used to cure a range of diseases for ages. In present study combination effect of volatile oils obtained from Trachyspermum ammi, Coriandrum sativumand Cymbopogon martiniiwere evaluated against four selected dermatophytic fungi namely Microsporum canis, M. fulvum, Trichophyton rubrumand T. mentarophytes.Materials and Methods: Four combinations like T. ammi+ Cymbopogon martinii, T. ammi+ Coriandrum sativum, Cymbopogon martinii+ C. sativum, T. ammi+ Cymbopogon martinii+ C. sativumwere prepared and evaluated through semisolid agar antifungal susceptibility methods.Results: During present investigation T. rubrumwas found to be most resistant fungus. Combination of T. ammiwith C. sativumshowed excellent results as compared to T. ammiand C. martinii. Combination of C. martiniiand C. sativumwas less effective as compared to other combinations. MIC was ranging from 0.1 μL/mL to 0.4 μL/mL against test fungi.Conclusion: Although essential oils are frequently combined in the use of aromatherapy to cure infectious disorders, there is very little data to back up this practice. This study supports the concurrent usage of blended essential oils in some way.

Keywords: Combination; Dermatophytes; Essential oil; MIC