Protective Activity of Rumex vesicarius Leaf Extract on Doxorubicin Induced Cardiotoxicity

Abstract

Background: Doxorubicin is an important and efficient anticancer medicine that is widely used to treat several types of cancer. However, its clinical use is limited due to dose-dependent cardiotoxicity. Elevated tissue levels of cellular superoxide anion/oxidative stress contribute to doxorubicin-induced cardiotoxicity.Objectives: The current study aimed to look into the protective effects of Rumex vesicarius leaves against the doxorubicin induced cardiotoxicity.Materials and Methods: In treatment schedule, thirty male Wistar albino rats were allocated into five groups of six animals each. Cardiotoxicity was induced by single dose administration of Doxorubicin (20 mg/kg b. wt). The standard group received Amlodipine (5 mg/kg b. wt) and treatment groups receivedRumex vesicariusleaves extract (200 and 400 mg/kg b. wt). Cardiac serum parameters-LDH, CK-MB, ALT, AST, and calcium and heart tissue LPO, GSH, and CAT levels were estimated.Results: Rats administered with doxorubicin have significantly increased cardiac serum parameters, tissue LPO, and Ca++-ATPase while significantly decreasing tissue GSH, CAT, Na+/K+-ATPase and Mg++-ATPase levels. Pretreatment with extract (400 mg/kg) showed significant protective activity against doxorubicin induced cardiotoxicity. Additionally, histopathological research was significantly reinforced the cardio protective effects of Rumex vesicarius leaves.Conclusion: Rumex vesicarius leaf extract showed significant cardioprotective activity against doxorubicin induced toxicity.

Keywords: Amlodipine; Doxorubicin; Membrane bound enzymes; Oxidative stress; Rumex vesicarius