GC-MS Analysis of Dhanwanthari Taila: Identification of Bioactive Compounds Supporting its Analgesic and Anti-Inflammatory Potential in Chronic Low Back Pain

Abstract

Background The scientific validation of traditional Ayurvedic formulations is crucial for integrating them into modern therapeutic practices. Dhanwanthari Taila, a widely used Ayurvedic medicated oil, is traditionally used for pain management, particularly in musculoskeletal disorders like Chronic Low Back Pain (CLBP). Aim and Objectives This study utilizes Gas Chromatography-Mass Spectrometry (GC-MS) to analyze the chemical composition of Dhanwanthari Taila, aiming to establish correlations between its bioactive compounds and its therapeutic effects in pain relief. Materials and Methods A sample (100 mL) of Dhanwanthari Taila was procured from KLE GMP certified Ayurveda Pharmacy and subjected to GC-MS analysis using standard analytical protocols to identify its bioactive components. Results and Discussion The analysis identified key bioactive compounds, including Glycidyl palmitoleate, Oleic acid, 1-Decyne, 3-Tridecene, and Hexadecanoic acid derivatives, which are known for their anti-inflammatory and analgesic properties. The high concentration of Glycidyl palmitoleate suggests its potential contribution to the oil’s therapeutic efficacy. These findings align with the traditional use of Dhanwanthari Taila in alleviating pain, inflammation, and stiffness, supporting its role in managing CLBP and related conditions. Conclusion The presence of these bioactive molecules validates the therapeutic application of Dhanwanthari Taila as an effective pain-relieving formulation. Further research is essential to explore its clinical efficacy and potential integration into conventional pain management strategies.

Keywords: Dhanwanthari Taila; GC-MS; Chronic Low Back Pain; Analgesic; Anti-Inflammatory