Article · Volume 17, Issue 4 · pp. 1315–1327
Exploring the Pharmacological Potential of Achyranthes aspera (Latzeera): A Complete Investigation of its Anticancer, Anti-Microbial and Antioxidant Activities
Arijit Chaudhuri1, Biswajit Dash2, Ashish Sarkar3, Afrin Alam4, Ayush Garg5, Shivani Devi1, Ankita Sharma1, Varsha Chauhan6, Tanbeer Kaur7, Yashna Bawa8
- 1Department of Pharmacology, Shiva Institute of Pharmacy, Luhnoo, Kanatain, Chandpur, Himachal Pradesh, INDIA.
- 2Department of Pharmaceutical Chemistry, Amity Institute of Pharmacy, Amity University, Kolkata, West Bengal, INDIA.
- 3Department of Pharmaceutical Chemistry, School of Pharmacy, YBN University, Ranchi, Jharkhand, INDIA.
- 4Department of Pharmaceutics, School of Pharmacy, YBN University, Ranchi, Jharkhand, INDIA.
- 5Department of Pharmaceutics, Venkateshwar Institute of Pharmacy, Sai Tirupati University, Udaipur, Rajasthan, INDIA.
- 6Department of Biotechnology, School of Science, Institute of Technology and Management University, Gwalior, Madhya Pradesh, INDIA.
- 7Department of Food Technology and Nutrition, School of Agriculture, Lovely Professional University, Phagwara, Punjab, INDIA.
- 8Department of Home Science, Sanatan Dharma College, Kurukshetra University, Ambala Cantt, Haryana, INDIA.
Abstract
Background: A medicinal herb called Achyranthes aspera has been used for centuries to treat a wide range of illnesses. By assessing its antineoplastic, anti-microbial and antioxidant properties. This study sought to thoroughly explore Achyranthes asperapharmacological potential.Materials and Methods: Antibacterial activity against a panel of bacterial strains was assessed using the disc diffusion method. To ascertain cell viability in cancer cell lines, anti-cancer activity was assessed using the MTT assay. The antioxidant activity of the plant extract was assessed by its capacity to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals.Results: Achyranthes aspera extract showed encouraging antibacterial efficacy against specific bacterial strains, however not as strong as the common antibiotic, ciprofloxacin. The MTT assay indicated possible anti-cancer efficacy by showing a notable dose-dependent reduction in cancer cell lines' cell viability. Through the scavenging of free radicals, the extract from Achyranthes asperaalso demonstrated strong antioxidant activity.Conclusion: The pharmacological potential ofAchyranthes aspera is strongly supported by this investigation, confirming its historic use in treating a variety of illnesses. Promising antioxidant, antimicrobial and anti-cancer properties were demonstrated by the plant extract. In order to determine the bioactive components, clarify the underlying mechanisms of action, assess the protection and efficacy of Achyranthes aspera extracts in preclinical, clinical contexts, these findings call for additional research.
Keywords: Achyranthes aspera; Antioxidant; Antimicrobial; Anti-cancer
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