Article · Volume 2, Issue 4 · pp. 211–214

Cytotoxic essential oil from Annona sengalensis Pers. leaves

A. L. Ahmed¹, S. E. M. Bassem², Y. H. Mohamed³, M. W. Gamila²

¹aDepartment of Health Information Technology of Jeddah Community College, King Abdul-Aziz University, Al- Rehab, 80283 Jeddah, Kingdom of Saudi Arabia
²Department Pharmacognosy, National Research Centre Dokki, 12622 Giza, Egypt
³Department Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Abstract

The cytotoxicity against brine shrimp of the essential oil obtained from the leaves of Annona senegalensis Pers. (Annonaceae) was studied. The confirmation of this toxicity has been done by using selected tumor cell lines (A549, HT29, MCF 7, RPMI, and U251). The results showed that the total oil and its fractions have showed mild to moderate cytotoxicity in brine shrimp lethality bioassay with LC50 = 27.3 μg/ml, and against some human tumor cell lines. The total oil and its fractions were analyzed by gas chromatography/mass spectroscopy (GC/MS). Seventy three compounds were identified.

Keywords: Annona senegalensis; GC/MS; essential oil; brine shrimp; cytotoxicity

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