Article · Volume 2, Issue 6 · pp. 359–363

Modulating effect of Gmelina arborea Linn. on immunosuppressed albino rats

S. H. Shukla¹, A. K. Saluja², S. S. Pandya³

¹*Indukaka Ipcowala College of Pharmacy, New Vallabh Vidyanagar, Dist. Anand, Gujarat - 388 121
²A.R.College of Pharmacy, Vallabh Vidyanagar, Dist. Anand, Gujarat - 388 120;
³Nutan Education Trust’s B. Pharmacy College, At. Rampura, Po. Kakanpur, Tal. Godhra, Dist. Panchmahal, Gujarat - 389 713, India

Abstract

Aim In the present study, the immunomodulatory effects of roots of Gmelina arborea Linn. were investigated. Materials and Methods Methanolic extract of G. arborea Linn. (MEGA) and its ethyl acetate fraction (EAFME) were used for evaluating the pharmacological activity. The modulating effect was evaluated on humoral and cell-mediated immune response using animal models like cyclophosphamide-induced myelosuppression, delayed-type hypersensitivity (DTH) response, and humoral antibody (HA) titre. Results Both test extracts produced significant increase in HA titre, DTH response, and levels of total white blood cell count. Conclusion This drug is found to be a potential immunostimulant.

Keywords: Cellular immunity; Gmelina arborea; Humoral immunity; Immunomodulation

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