Communication · Volume 3, Issue 2 · pp. 143–145

Chemical constituents and biological studies of Origanum vulgare Linn.

Gottumukkala Venkateswara Rao¹, T. Mukhopadhyay¹, T. Annamalai¹, N. Radhakrishnan¹, M. R. Sahoo¹

¹CavinKare Research Centre, Ekkattuthangal, Chennai – 600 032, India

Abstract

Bioassay-guided isolation of methanolic extract of the leaves of Origanum vulgare Linn., yielded two protocatechuic acid ester derivatives, origanol A (1) and origanol B (2) along with ursolic acid (3), oleanolic acid (4), β-sitosterol (5), and triacontanol (6). Structures of the compound were established based on physical and spectral data (UV, IR, 1H and 13C NMR and mass). Origanol A (1) showed significant mushroom tyrosinase inhibition activity.

Keywords: Origanum vulgare Linn; origanol A and B; triterpene acids; tyrosinase inhibition; β-sitosterol

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