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PR · Lens · In vitro H+ -K+ ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.

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Communication · Volume 4, Issue 2 · pp. 123–126

In vitro H+ -K+ ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.

Priyanka Yadav1, Aditya Ganeshpurkar1, Gopal Rai2

  1. 1Department of Pharmacology, Shri Ram Institute of Technology -Pharmacy, Jabalpur, Madhya Pradesh
  2. 2Department of Pharmacy, Guru Ramdas Khalsa Institute of Science and Technology, Jabalpur, Madhya Pradesh, India

Abstract

Objective This study was undertaken to study in vitro H+-K+ ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn. Materials and Methods Total phenolic and flavonoid contents from extract was quantified and H+-K+ ATPase inhibition assay was performed in presence of different concentrations of standard (omeprazole) and methanol extract. Results Extract showed significant (*P < 0.05) proton pump inhibitory activity in the goat gastric mucosal homogenate which was comparable to standard. Conclusions These findings showed that methanolic extract of C. quadrangularis Linn. is potent inhibitor of proton pump.

Keywords: Cissus quadrangularis Linn; H+-K+ ATPase inhibition assay; in vitro

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