Article · Volume 4, Issue 4 · pp. 225–229

In vitro anti-plasmodial activity of three herbal remedies for malaria in Ghana: Adenia cissampeloides (Planch.) Harms., Termina liaivorensis A. Chev, and Elaeis guineensis Jacq

Kofi Annan, K. Sarpong¹, C. Asare¹, R. Dickson¹, KI. Amponsah¹, B. Gyan³, M. Ofori³, SY. Gbedema²

¹Departments of Pharmacognosy
²Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, KNUST, Kumasi
³Department of Immunology, Noguchi Memorial Institute for Medical Research, Legon, Accra

Abstract

Background Herbal remedies of Adenia cissampeloides, Terminalia ivorensis, and Elaeis guineensis among others have been used in Ghana for the treatment of various ailments including malaria. However, most of these remedies have not been scientifically investigated. Objective This study, therefore, seeks to investigate the anti-plasmodial activity of these plants. Materials and Methods The ethanolic extracts of A. cissampeloides stem, T. ivorensis stem bark, and E. guineensis leaves were tested for in vitro anti-plasmodial activity against chloroquine-resistant strains of Plasmodium falciparum. Thin blood films were used to assess the level of parasitemia and growth inhibition of the extracts. Results The IC50 of A. cissampeloides, T. ivorensis, and E. guineensis were 8.521, 6.949, and 1.195 mg/ml, respectively, compared to artesunate with IC50 of 0.031 mg/ml. Conclusion The result of this study appears to confirm the folkloric anti-malarial use these plants.

Keywords: Adenia cissampeloides; anti-plasmodial; Elaeis guineensis; herbal remedies; Terminalia ivorensis

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