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PR · Lens · New triterpenoid acyl derivatives and biological study of Manilkara zapota (L.) Van Royen fruits

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Review · Volume 5, Issue 2 · pp. 55–59

New triterpenoid acyl derivatives and biological study of Manilkara zapota (L.) Van Royen fruits

Nesrin M. Fayek1, Azza R. Abdel Monem1, Mohamed Y. Mossa1, Meselhy R. Meselhy1

  1. 1Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt

Abstract

b-amyrin-3-(3'-dimethyl) butyrate, a new natural compound was isolated from the fruits of Manilkara zapota (L.) Van Royen, in addition to lupeol-3-acetate and 4-caffeoylquinic acid (cryptochlorogenic acid). The structures of these compounds were identified using different spectral methods (IR, MS, UV, 1H-NMR, 13C-NMR and 2D-NMR). The alcoholic and aqueous extracts of the unripe fruits, in addition to their aqueous homogenate exhibited antioxidant, antihyperglycemic and hypocholesterolemic activities.

Keywords: 4-caffeoylquinic acid; antihyperglycemic; antioxidant; b-amyrin-3-(3'-dimethyl) butyrate; hypocholesterolemic; lupeol-3-acetate; Manilkara zapota

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