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PR · Lens · Bronchodilatory effect of ethanolic extract of the leaves of Nyctanthes arbortristis

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Article · Volume 5, Issue 3 · pp. 169–172

Bronchodilatory effect of ethanolic extract of the leaves of Nyctanthes arbortristis

Ramadan B. Sopi1, Muhammad Feroz Hayat Khan2

  1. 1Department of Pharmacy-Biology, University of Prishtina, Prishtina, Kosovo
  2. 2Department of Biomedical Sciences, Centre for Biomedical Research, University of Dhaka, Bangladesh

Abstract

Background Nyctanthes arbortristis has been used in traditional medicine for the treatment of asthma and cough. Aim In this study, bronchodilatory effect of ethanolic extract of the N. arbortristis was investigated under in vitro conditions. The concentration–response curve of the tracheal smooth muscle (TSM) to histamine was recorded in presence or absence of ethanolic extract and Nw-nitro-l-arginine methyl ester (L-NAME). Dose–response effect of ethanolic extract on pre-constricted tissues was investigated. The ethanolic extract inhibited the histamine-induced maximum contractile responses of TSM (P < 0.001). Ethanolic extract also cause dose-dependent relaxation of TSM. These effects were reversed by L-NAME. Phytochemical analysis showed the presence of typical plant constituents. These results suggest the possible use of extract of the leaves of N. arbortristis as a bronchodilator in therapeutic treatment of asthma.

Keywords: Asthma; ethanolic extract Nyctanthes arbortristis; tracheal smooth muscle

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