Article · Volume 5, Issue 3 · pp. 195–199
Phytochemical screening and cytotoxicity studies of Chrysophyllum pruniforme Pierre ex Engl. barks
Sophie Aboughe Angone1, L. Mewono2, M. Boukandou Mounanga1, S. Medzegue3, H. F. Ella Mendene1, J.G. Mba Ndong1, J. F. Djoba Siawaya3, A. Souza4
- 1Pharmacopea and Traditional Medicine Institute, National Center of Technological and Scientific Research
- 2Medical Research unit Albert Schweitzer Hospital, Lambaréné
- 3National Laboratory of Public Health, Libreville
- 4National Institute of Agronomy and Biotechnology, Franceville, Gabon
Abstract
Background Chrysophyllum pruniforme of family sapotaceae is a plant used in traditional medicine in Gabon. Materials and Methods In this study, C. pruniforme barks were subjected to phytochemical screening and cytotoxicity investigations. Different concentrations of aqueous and total phenolic extract were tested on mice and on human erythrocytes. Results Phytochemical screening of C. pruniforme barks revealed the presence of flavonoids, saponins, and tannins, reducing sugars, polyphenols and traces of anthraquinones. When tested in vitro, aqueous and the phenolic extracts showed hemolytic activities on human erythrocytes with phenolic compounds being more cytotoxic than aqueous extracts. In vivo study of toxicity, allowed to determine the LD50 at 90 mg/kg for the doses of 50, 150 and 250 mg/kg of body weight. Conclusion These data indicate in one hand that C. pruniforme is rich in phenolic compounds and that the aqueous and total phenolic extracts could be considered as toxic for mice and maybe potentially toxic to humans in the other hand.
Keywords: Chrysophyllum; pruniforme; cytotoxicity polyphenols; phytochemical screening
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