Article · Volume 5, Issue 4 · pp. 306–308
Mast cell stabilization potential of Sitopaladi churna: An ayurvedic formulation
Inder K. Makhija1, Chandrashekara S. Shreedhara1, H. N. Aswatha Ram1
- 1Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Karnataka, India
Abstract
Background Sitopaladi churna (SPC) is a popular polyherbal ayurvedic formulation used in the treatment of allergy and respiratory diseases. Objective The present study was aimed to justify the classical use of antiallergic claim by performing the mast cell stabilizing activity of extracts of SPC. Materials and Methods The protective effect of aqueous extract and methanolic extract - of SPC against compound 48/80-induced mast cell degranulation model was carried out. Results Sitopaladi churna aqueous extract (SPCA) at the dose of 300 mg/kg and Sitopaladi churna methanolic extract (SPCM) at the doses of 150 and 300 mg/kg showed better protection of mast cell degranulation (65%-74%) and were comparable to the standard drug ketotifen (79%), when peritoneal mast cells were treated with compound 48/80. The protection against mast cell degranulation was significant (P < 0.0001). Conclusion From the above results, it has been justified that SPC can be used to treat allergic disorders.
Keywords: Compound 48/80; mast cell stabilizing; Sitopaladi churna
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