Review · Volume 7, Issue 3 · pp. 225–236
Review of clinical studies of Polygonum multiflorum Thunb. and its isolated bioactive compounds
Guy-Armel Bounda1, YU Feng1,2
- 1Department of Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009
- 2Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Ministry of Education, China
Abstract
Polygonum multiflorum Thunb. (PMT), officially listed in the Chinese Pharmacopoeia, is one of the most popular perennial Chinese traditional medicines known as He shou wu in China and East Asia, and as Fo-ti in North America. Mounting pharmacological studies have stressed out its key benefice for the treatment of various diseases and medical conditions such as liver injury, cancer, diabetes, alopecia, atherosclerosis, and neurodegenerative diseases as well. International databases such as PubMed/Medline, Science citation Index and Google Scholar were searched for clinical studies recently published on P. multiflorum. Various clinical studies published articles were retrieved, providing information relevant to pharmacokinetics-pharmacodynamics analysis, sleep disorders, dyslipidemia treatment, and neurodegenerative diseases. This review is an effort to update the clinical picture of investigations ever carried on PMT and/or its isolated bio-compounds and to enlighten its therapeutic assessment.
Keywords: Clinical pharmacokinetics; clinical studies; herbal hepatotoxicity; Polygonum multiflorum Thunb; therapeutic assessment
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