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PR · Lens · Hepatoprotective and Cytotoxic Activities of Abietic Acid from Isodon wightii (Bentham) H. Hara

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Communication · Volume 8, Issue 3 · pp. 206–208

Hepatoprotective and Cytotoxic Activities of Abietic Acid from Isodon wightii (Bentham) H. Hara

Madhusudhanan Gogul Ramnath1, Ramaraj Thirugnanasampandan1, Sadasivam Mathusalini2, Palathurai Subramanium Mohan2

  1. 1Department of Biotechnology, Kongunadu Arts and Science College
  2. 2Department of Chemistry, Bharathiar University, Coimbatore, Tamil Nadu, India

Abstract

Isodon (Lamiaceae) is a known source of bioactive terpenoids. Diterpenoids isolated from Isodon wightii (Bentham) H. Hara showed antibacterial, antiacetylcholinesterase, antioxidant, anticancer, and anticarcinogenic activities, etc., Hepatoprotective activity of ABA against lipopolysaccharide (LPS) induced liver injury in BALB/c mice was studied. Cytotoxic activity of ABA was tested against cervical cancer cells (HeLa) using MTT assay followed by propidium iodide (PI) staining to identify apoptosis. Histopathological analysis revealed that 1.5 mg/mL LPS induced liver damage was attenuated by ABA in a dose dependent manner. ABA showed cytotoxicity with IC50 value of 176.28 ± 0.02 mg/mL and PI staining of treated cells showed apoptosis. This study proves that ABA would be a promising natural compound for herbal drug preparation.

Keywords: Abietic acid; apoptosis; BALB/c mice; HeLa; lipopolysaccharide

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