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PR · Lens · Antidiabetic Effects of Aqueous and Dichloromethane/Methanol Stem Bark Extracts of Pterocarpus soyauxii Taub (Papilionaceae) on Streptozotocin‑induced Diabetic Rats

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Article · Volume 9, Issue 1 · pp. 80–86

Antidiabetic Effects of Aqueous and Dichloromethane/Methanol Stem Bark Extracts of Pterocarpus soyauxii Taub (Papilionaceae) on Streptozotocin‑induced Diabetic Rats

Marie Claire Tchamadeu1, Paul Désiré Djomeni Dzeufiet2, Nelly Blaes3, Jean-Pierre Girolami3, Pierre Kamtchouing2, Théophile Dimo2

  1. 1Department of Animal Biology Organisms, Faculty of Science, University of Douala, 24157, Douala; Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, 812, Yaounde, Cameroon; INSERM, U1048, I2MC Institute of Metabolic and Cardiovascular diseases, University of Toulouse III, F31432, Toulouse, FRANCE.
  2. 2Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde 1, 812, Yaounde, CAMEROON.
  3. 3INSERM, U1048, I2MC Institute of Metabolic and Cardiovascular diseases, University of Toulouse III, F31432, Toulouse, FRANCE.

Abstract

Aim of the Study:The aim is to evaluate the hypoglycemic and antidiabetic effects of aqueous and CH2Cl2/CH3OH stem bark extracts of Pterocarpus soyauxiiTaub in normal and diabetic rats.Materials and Methods: Streptozotocin (STZ)‑induced diabetic and normal adult Wistar rats were orally administered with aqueous and CH2Cl2/CH3OH plant extracts of P. soyauxiiat various doses (38–300 mg/kg) in a single administration. In addition, STZ‑induced diabetic rats received prolonged daily administration for 14 days. Glibenclamide (GB) (10 mg/kg) was used as reference treatment. In acute test, fasting blood glucose was followed for 5 h. In subacute test, body weight, food and water intakes, and blood glucose were followed weekly and serum biochemical parameters evaluated after 14 days treatment.Results: Acute administration of aqueous and CH2Cl2/ CH3OH stem bark extracts moderately decreased fasting blood glucose compared to GB, significantly in normal rats (P< 0.05 to P < 0.01) but, as GB, not significantly in diabetic rats. Prolonged treatments in diabetic rats with aqueous and CH2Cl2/CH3OH extracts reduced blood glucose to an extent, respectively, superior or similar to GB. Moreover, P. soyauxii also significantly (P < 0.01) reduced weight loss, and diabetes increased serum triglycerides, total cholesterol, and transaminases (alanine aminotransferase/ aspartate aminotransferase) elevations.Conclusion: P. soyauxiiTaub stem bark extracts have possible value for antidiabetic oral medication.

Keywords: Antihyperglycemic; Diabetes mellitus; Phytotherapy; Pterocarpus soyauxii Taub; Rats; Streptozotocin

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