Review · Volume 15, Issue 30 · pp. 128–133
Recent Updates in Research on Gymnema sylvestre
Pallavi Shrirang Jamadagni1, Sharad D. Pawar2, Shrirang B. Jamadagni1, Manish Gautam4, Sudesh N. Gaidhani3, G.P. Prasad1, Arun M. Gurav1
- 1Regional Ayurveda Research Institute, CCRAS; Min. of AYUSH, Nehru Garden, Kothrud, Pune, Maharashtra, INDIA.
- 2Central Ayurveda Research Institute, CCRAS; Min. of AYUSH, 4 CN Block, Kolkata, West Bengal, INDIA.
- 3Headquarters, Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Govt. of India, Janakpuri, New Delhi, INDIA.
- 4Department of Pharmaceutical Technology, School of Medical Sciences, Adamas University, Kolkata, West Bengal, INDIA.
Abstract
Gymnema sylvestrae (GS) is a large woody climbing plant that is available in dry forests of India and China. It is also proven for other activities like anti-hemolytic, anti-bacterial and anti-cancer. Present review covers recent updates in research on this plant typically during last 10 years. Also, its characterization and extraction, structure activity relationship, in-vitro pharmacology, in-vivo pharmacology, pharmacodynamics, clinical pharmacology and clinical efficacy, safety and toxicity is discussed in details. Detailed review of available literature on GS indicates it is promising plant for treatment of Type 2 Diabetes Mellitus. GS acts only in presence of pancreas as it acts by stimulation of β cells of langerhans. However, it has also shown hepatotoxic property.
Keywords: Gymnema sylvestre; Diabetes; Pharmacology; Gymnemangenin; Gymnemic acid
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