Bioactive Potential of Salicornia europaea Extracts Antioxidant, Anti-Inflammatory, Antivenom, and Anticancer Assay on HepG2 Apoptosis Induction

Abstract

Background: As an ethnomedical herb, Salicornia europaea is widely used in India to cure a variety of illnesses.Objectives: The present studies evaluated an aqueous extract of Salicornia europaea for its anti-inflammatory, antioxidant, anticancer, apoptotic, and anti-venom qualities.Materials and Methods: The DPPH photometric assay, OH radical scavenging capacity, anti-inflammatory activity, Cyclooxygenase (COX), Lipoxygenase (LOX), anticancer, apoptotic, and anti-venom action are a few examples of in vitro models that were used to measure antioxidant activity.Results: The study supported the traditional use of the aforementioned plants in inflammatory disorders by finding that the antioxidant and anti-inflammatory effects of plant extracts may be due to the inhibition of DPPH and OH, COX, and LOX enzymes, respectively. Salicornia europaea's aqueous extract was extremely selective (p<0.005) against HepG2 cells, generating morphological changes, according to the MTT experiment.Conclusion: Because of its strong PLA2 inhibition, the aqueous extract of Salicornia europaea was found to have the strongest and safest anti-inflammatory, antioxidant, anticancer, and anti-venom properties based on the available data.

Keywords: Cyclooxygenase; DPPH; Hydroxyl; Inflammation; lipoxygenase; Salicornia europaea