Article · Volume 14, Issue 2 · pp. 382–385
Evaluation of Analgesic Activity of the Siddha Polyherbal Formulation Ettikottai Mathirai Using Eddy’s Hot Plate Method in Mice
Kesavarajan Shanmugam1
- 1Department of Gunapadam (Siddha Pharmacology), National Institute of Siddha, Chennai, Tamil Nadu, INDIA.
Abstract
Background: Ettikottai Mathirai (EM) is a classical Siddha polyherbal formulation traditionally used to manage pain.Objectives: Evaluate analgesic potential of EM using Eddy's Hot Plate method in mice.Materials and Methods: Vehicle control, Pentazocine (5 mg/kg) standard, and EM low and high doses (8.5, 17 mg/kg) tested.Results: Dose-dependent increase in latency observed; high dose comparable to standard.Conclusion: EM exhibits analgesic activity suggesting central pain pathway involvement; further studies recommended.
Keywords: Ettikottai Mathirai; Analgesic; Hot plate method
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