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Asian Journal of Biological and Life sciencesNOW IN
Article

Evaluation of Analgesic Activity of the Siddha Polyherbal Formulation Ettikottai Mathirai Using Eddy’s Hot Plate Method in Mice

Kesavarajan Shanmugam1★★ Corresponding author

  1. 1Department of Gunapadam (Siddha Pharmacology), National Institute of Siddha, Chennai, Tamil Nadu, INDIA.

CORRESPONDENCE

Kesavarajan Shanmugam

PG Scholar, Department of Gunapadam (Siddha Pharmacology), National Institute of Siddha, Chennai-600047, Tamil Nadu, INDIA.

kesavshanmugam1997@gmail.com

Received: 12-02-2025; Revised: 09-04-2025; Accepted: 24-06-2025.

Volume 14, Issue 2 · pp. 382–385 · PUBLISHED May-Aug 2025 · DOI: 10.5530/ajbls.20251503

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ABSTRACT

Background: Ettikottai Mathirai (EM) is a classical Siddha polyherbal formulation traditionally used to manage pain. Objectives: Evaluate analgesic potential of EM using Eddy's Hot Plate method in mice. Materials and Methods: Vehicle control, Pentazocine (5 mg/kg) standard, and EM low and high doses (8.5, 17 mg/kg) tested. Results: Dose-dependent increase in latency observed; high dose comparable to standard. Conclusion: EM exhibits analgesic activity suggesting central pain pathway involvement; further studies recommended.

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    Shanmugam, K. (2025). Evaluation of Analgesic Activity of the Siddha Polyherbal Formulation Ettikottai Mathirai Using Eddy’s Hot Plate Method in Mice. Asian Journal of Biological and Life sciences, 14(2), 382–385. https://doi.org/10.5530/ajbls.20251503