Article · Volume 14, Issue 2 · pp. 400–409
Identification of Hub Genes and Therapeutic Targets in Lung Cancer Using Software Tools
S. Anbuselvi1, S. Saranya1
- 1Department of Biotechnology, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, INDIA.
Abstract
Background: Lung cancer remains a leading cause of cancer deaths.Objective: Identify hub genes associated with lung cancer via GEO curation and PPI/network analyses to prioritize therapeutic targets.Methods: Functional enrichment (DAVID, ShinyGO), druggability assessment (ChEMBL, Pharos).Results: Top hub genes and enriched pathways reported; chemokine receptor activity and T-cell receptor related functions highlighted.Conclusion: Prioritized hub genes provide resources for experimental validation.
Keywords: Lung Cancer; Hub genes; PPI; Therapeutic targets
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